Rui Chen

Metabolic reprogramming via SIRT2-deficient microglial large extracellular vesicles ameliorates alzheimer’s pathology

Xiaolu Tang, Rui Chen, Jiawei Xing, Qing Huang et autres

BACKGROUND: Current therapies for Alzheimer's disease (AD) offer only symptomatic relief, highlighting the urgent need for disease-modifying approaches capable of halting or reversing neurodegeneration. Extracellular vesicles (EVs) have attracted growing interest as therapeutic vehicles owing to their inherent capacity to bypass the …

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Post Hoc Analysis of Solriamfetol Efficacy in Obstructive Sleep Apnea Patients with Excessive Daytime Sleepiness Stratified by Disease Severity

Changjun Su, Jiucheng Shen, Kaida Guo, Jing Wang et autres

INTRODUCTION: Solriamfetol, a dopamine and norepinephrine reuptake inhibitor, is indicated for the treatment of excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA). This study aims to evaluate the efficacy and safety profiles of solriamfetol across different severity levels of OSA …

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Relationship between maternal social support and undernutrition among children under 5 years in Siem Reap Province, Cambodia: the chain mediating roles of household food insecurity and maternal depression

Mengleang Rek, Nabila Ibn Ziyat, Rui Chen, Xixing Xu et autres

BACKGROUND: Undernutrition among children under five years (CUFY) is a leading global public health issue worldwide, including in Cambodia. This study aimed to determine the prevalence of undernutrition and the mediating effect of maternal depression and household food insecurity on the association …

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Association between Anti-Helicobacter pylori IgG seropositivity on coronary heart disease and potential pathogenesis: a Mendelian randomization study

Jing Wang, Tianying Chang, Yiqiang Wang, Jinling Zhang et autres

BACKGROUND: Currently, observational studies and clinical trials have shown that the occurrence of coronary heart disease (CHD) is closely related to anti-Helicobacter pylori (H. pylori) IgG seropositivity, but these studies may be affected by confounding factors, resulting in a causal relationship that …

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Selenium-binding protein 1 suppresses cell cycle progression via cyclin-dependent kinase 2 breakdown in colon carcinoma

Xiaotian Zhang, Dong Zhang, Qichang Liu, Zhipeng Cao et autres

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Osteochondral Lesion of the Talus Amplifies Plantar Pressure Alterations and Postural Instability in Chronic Lateral Ankle Instability: A Cross‐Sectional Study Based on a Wearable Smart Plantar Pressure System

Ting Zhu, Rui Chen, Haoyang Kang, F. Ding et autres

BACKGROUND: Chronic lateral ankle instability (CLAI) is frequently complicated by osteochondral lesion of the talus (OLT), which accelerate cartilage degeneration due to abnormal stress concentration and may progress to ankle osteoarthritis. However, in vivo biomechanical alterations in patients with concurrent CLAI and …

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Discovery and validation of proliferative exhausted T cells as a favorable prognostic biomarker in esophageal squamous cell carcinoma

Gang Li, Rui Chen, Xinran Wang, Hao Zhang et autres

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapies and poor prognosis. While exhausted T cell (Tex) heterogeneity under chronic antigen stimulation is recognized, the role of Tex subsets in shaping the tumor microenvironment (TME) and influencing ESCC outcomes …

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Role of non-coding RNAs in radiotherapy sensitivity in non-small cell lung cancer

Peipei Yang, Rui Chen, Huijuan He

Lung cancer (LC) is consistently the leading cause of cancer-related deaths worldwide. Radiotherapy is a crucial means of treating LC, and about 60-70% of LC patients require radiotherapy. However, radiotherapy resistance remains a significant challenge for treatment outcomes. Non-coding RNAs (ncRNAs) are …

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Does facet tropism influence the clinical outcomes of posterior lumbar interbody fusion for degenerative lumbar spondylolisthesis?

Tianyi Wu, Yun Teng, Hao Yu, Junjie Niu et autres

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Abstract 4365285: A Phase I, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of N-acetylgalactosamine Small Interfering RNA Conjugate, BPR-30221616, in Healthy Participants, for Potential Treatment of Transthyretin Amyloidosis

Xiaohong Han, Rui Chen

Introduction: Transthyretin amyloidosis (ATTR) is a progressive disease characterized by abnormal buildup amyloid of misfolded transthyretin (TTR) protein in multiple organs and the major disease manifestations include polyneuropathy and cardiomyopathy. The pathogenic amyloid accumulation results in organ dysfunction and reduced life expectancy. …

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An open-label Phase II trial of VDJ-001, a high-affinity IL-6R antagonist antibody, for the treatment of patients with idiopathic multicentric castleman disease

Lu Zhang, Rui Chen, Yujun Dong, Q. Wang et autres

Abstract Interleukin-6 (IL-6) targeted therapy has been recommended as the most important treatment option for idiopathic Multicentric Castleman Disease (iMCD). Although siltuximab has been approved in many countries, this first IL-6 blocking antibody only revealed a beneficial effect for 34% of patients …

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1339 A randomized, double-blind, placebo-controlled, dose-escalated, first-in-human study to assess the safety, tolerability, and T cell replenishment of JL18008, a long-acting IL-7, in healthy subjects

Sarah A. Johnson, Rui Chen, Qian Zhao, Cuifang Hao et autres

Background JL18008 is a genetically engineered fusion protein of human serum albumin (HSA) and IL-7 designed for clinical use with an enhanced half-life. The preclinical data showed that JL18008 recovered T cell counts in lymphocytopenic animal models. This study is a first-in-human, …

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