Accès ouvert
2025
article
OpenAlex
Wen‐Rui Hao, Chun‐Chao Chen, Jia-Hong Lin, Huan‐Yuan Chen et autres
Background/Objectives: Mitophagy, the selective removal of damaged mitochondria, plays a pivotal role in regulating cardiac hypertrophy and fibrosis under pressure overload. Targeting mitophagy may help mitigate adverse cardiac remodeling. This preclinical study examined the effects of cafestol, a coffee-derived diterpene, on pressure …
tw
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Accès ouvert
2025
article
OpenAlex
Wen‐Rui Hao, Chun‐Chao Chen, Fu‐An Li, Huan-Yuan Chen et autres
Pressure-overload-induced heart failure is characterized by pathological ventricular remodeling, including hypertrophy and fibrosis, which compromise cardiac function and worsen outcomes. Vericiguat, a soluble guanylate cyclase (sGC) stimulator, has shown therapeutic promise in heart failure with reduced ejection fraction (HFrEF). This study evaluated …
tw
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Wen‐Rui Hao, Fu‐An Li, Huan‐Yuan Chen, Tzu‐Hurng Cheng et autres
Cardiac hypertrophy and fibrosis are hallmark responses to pressure overload, driving the progression of heart failure. Fucoidan, a sulfated polysaccharide derived from brown algae, has demonstrated anti-inflammatory and antioxidant effects in cardiovascular models. Building on prior evidence of its ability to suppress …
tw
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hung-Hsin Chao, Tzu-Hurng Cheng, Chun‐Chao Chen, Ju-Chi Liu et autres
L. (HS), native to Eastern and Southern Asia, has been traditionally used in Asian herbal medicine for its anticancer, antimicrobial, and anti-inflammatory properties. Despite these recognized bioactivities, its potential cardioprotective effects, particularly in the setting of heart failure (HF), remain largely unexplored. …
tw, us
(code pays fourni par la source)
2019
article
OpenAlex
Wen-Rui Hao, Li‐Chin Sung, Chun‐Chao Chen, Hong-Jye Hong et autres
Through population-based studies, associations have been found between coffee drinking and numerous health benefits, including a reduced risk of cardiovascular disease. Active ingredients in coffee have therefore received considerable attention from researchers. A wide variety of effects have been attributed to cafestol, …
tw
(code pays fourni par la source)
2018
article
OpenAlex
Ting‐Tse Lin, Jimmy Jyh-Ming Juang, Jen-Kuang Lee, Chia‐Ti Tsai et autres
OBJECTIVE: To evaluate whether home or ambulatory blood pressure (BP) monitoring was associated with preclinical hypertensive cardiovascular target organ damage (TOD). METHODS: We enrolled participants with prehypertension and stage 1 hypertension from 11 medical centers within the Taiwan hypertension-associated cardiac disease consortium. …
tw
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Accès ouvert
2018
article
OpenAlex
Wen-Rui Hao, Li‐Chin Sung, Chun‐Chao Chen, Po‐Yuan Chen et autres
Moderate coffee consumption is inversely associated with cardiovascular disease mortality; however, mechanisms underlying this causal effect remain unclear. Cafestol, a diterpene found in coffee, has various properties, including an anti-inflammatory property. This study investigated the effect of cafestol on cyclic-strain-induced inflammatory molecule …
tw, us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Hung‐Hsing Chao, Po‐Yuan Chen, Wen-Rui Hao, Wei-Ping Chiang et autres
BACKGROUND: This study investigated whether lipopolysaccharide (LPS) increase protease-activated receptor-2 (PAR-2) expression and enhance the association between PAR-2 expression and chemokine production in human vascular endothelial cells (ECs). METHODS: The morphology of ECs was observed through microphotography in cultured human umbilical vein …
tw
(code pays fourni par la source)
2016
article
OpenAlex
Hung‐Hsing Chao, Hong-Jye Hong, Tzu‐Hurng Cheng, Neng‐Lang Shih et autres
BACKGROUND: Nicorandil, a mitochondrial adenosine triphosphate-sensitive potassium (mitoKATP) channel opener, exerts protective effects on the cardiovascular system. This study examined the effect of nicorandil on cyclic strain-induced interleukin-8 (IL-8) expression in human umbilical vein endothelial cells (HUVECs). METHODS: Cultured HUVECs were exposed …
tw, us, jp
(code pays fourni par la source)
2016
article
OpenAlex
Shaowei Zhuang, Tzu‐Hurng Cheng, Nang-Lang Shih, Ju‐Chi Liu et autres
Tanshinone IIA is the main effective component of Salvia miltiorrhiza, known as "Danshen," which has been used in many therapeutic remedies in traditional Chinese medicine. However, the direct effects of tanshinone IIA on vascular endothelial cells have not yet been fully described. …
cn, tw
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Accès ouvert
2015
article
OpenAlex
Cho‐Kai Wu, Mao-Yuan Marine Su, Jen-Kuang Lee, Fu‐Tien Chiang et autres
Heart failure with preserved ejection fraction (HFPEF) is characterized by myocardial interstitial fibrosis. A total of 146 patients with HFPEF, were recruited. HFPEF severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). Canine modeling of HFPEF was …
tw
(code pays fourni par la source)
2015
article
OpenAlex
Wei‐Shiung Lian, Herng-Cheng Chiou, Heng Lin, Jin-Jer Chen et autres
Doxorubicin (DOX) is widely used as an anti-cancer agent although it causes irreversible cardiomyopathy by increasing oxidative stress and deregulating nitric oxide production. Beraprost (BPS), a stable prostacyclin (PGI2) analog, is a potent vasodilator that has beneficial effects on myocardial ischemia. The …
tw
(code pays fourni par la source)