Natália Lima Pessoa

In Vivo Characterization and Tissue Tropism of a Wild-Type Yellow Fever Virus Isolate from the 2017–2018 Brazilian Outbreak in C57BL/6 IFNAR1−/− Mice

Ana Luiza Campos Cruz, Natália Lima Pessoa, Eliane Silva, Sabrynna Brito Oliveira et autres

Yellow fever remains a significant public health concern in endemic regions of South America and Africa, where periodic outbreaks continue to challenge surveillance and control efforts. Despite the widespread use of vaccines and historical YFV strains in experimental settings, there is limited …

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Neuro-COVID-19 With or Without the Multisystem Inflammatory Syndrome (MIS-C): A Single-Center Study

Aline Almeida Bentes, Walter Rebuite dos Santos, Natália Lima Pessoa, Thaís Alkifeles Costa et autres

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O papel de receptores do Tipo Toll (TLRS) na resposta às infecções por Zika virus, Dengue virus e SARS-COV-2

Natália Lima Pessoa

Viral infections are a global public health problem and a severe social and economic burden. In viral infections, the immune system protects the body, with the innate immune system being the first line of defense to be activated. The detection of viruses …

GUILLAIN-BARRÉ ASSOCIADO À INFECÇÃO POR SARS-COV-2 EM LACTENTE

Aline Almeida Bentes, Natália Lima Pessoa, Lílian Martins Oliveira Diniz, Renata Barandas Mendes et autres

A síndrome de Guillain-Barré (SGB) é doença imuno mediada que caracteristicamente apresenta-se com fraqueza muscular ascendente progressiva e simétrica, redução dos reflexos tendíneos profundos e déficts motores. 1 A SGB ocorre mais frequentemente em adultos e idosos, e este é o primeiro …

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Children with sickle cell disease and severe COVID‐19 presenting single nucleotide polymorphisms in innate immune response genes – A case report

Natália Lima Pessoa, Lílian Martins Oliveira Diniz, Adriana de Souza Andrade, Erna Geessien Kroon et autres

Abstract Here we report three clinical cases of children with sickle cell disease (SCD) and severe COVID‐19 who evolved with complications during hospitalization or after discharge. They present single nucleotide polymorphisms in tlr‐7 and tirap genes, identified from 37 patients under 16 …

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Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism

Natália Lima Pessoa, Aline Almeida Bentes, Andréa Lucchesi de Carvalho, Thaís Bárbara de Souza Silva et autres

BACKGROUND: Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host …

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Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2

André Cronemberger Andrade, Patrícia Batista Xander, Rodrigo Pedro Soares, Natália Lima Pessoa et autres

Extracellular vesicles (EVs) shed by trypomastigote forms of Trypanosoma cruzi have the ability to interact with host tissues, increase invasion, and modulate the host innate response. In this study, EVs shed from T. cruzi or T.cruzi-infected macrophages were investigated as immunomodulatory agents …

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Subcutaneous Model for the Study of Dengue Virus Infection in Immune Competent Mice

Beatriz Senra Álvares da Silva Santos, Natália Lima Pessoa, Natália Lucinda, Gustavo Pereira Cardoso-Oliveira et autres

Various mouse models to study dengue have been described by different authors, some of them using immunodeficient or some using humanized mice. Our group reported previously a deadly murine model, which used the intracranial inoculum of highly virulent Dengue virus (DENV) in …

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Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B

Natália Lucinda, Maria Marta Figueiredo, Natália Lima Pessoa, Beatriz Senra Álvares da Silva Santos et autres

Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also blindness and encephalitis. It was previously shown that the immune response against HSV-1 occurs mainly in the trigeminal ganglia (TG) and that Toll-like receptors 2 and 9 (TLR2/9) are …

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Estudo da resposta imune inata celular in vitro contra Dengue virus e Zika virus

Natália Lima Pessoa

Dengue virus (DENV) e Zika virus (ZIKV) pertencem ao gênero Flavivirus da família Flaviviridae. São arbovirus transmitidos por mosquitos do gênero Aedes, porém, outros modos de transmissão vêm sendo relatados para ZIKV, como a transmissão vertical e sexual. DENV possui quatro sorotipos …

Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection

Paula Monalisa Nogueira, Rafael Ramiro de Assis, Ana Cláudia Torrecilhas, Elvira M. Saraiva et autres

The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in sugars that …

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Differential modulation of macrophage response elicited by glycoinositolphospholipids and lipophosphoglycan from Leishmania (Viannia) shawi

Luiz Felipe Domingues Passero, Rafael Ramiro de Assis, Thays N.F. da Silva, Paula Monalisa Nogueira et autres

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