Hans‐Henrik Stærfeldt

Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo‐Orozco et autres

In the version of this article initially published, Cristina Leal Rodríguez (Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) was omitted from the author list. The error has been corrected in the …

dk, it, gb, ch, de, se, nl, fr, fi, us, si, sg, es (code pays fourni par la source)

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo‐Orozco et autres

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based …

dk, it, gb, ch, de, se, nl, fr, fi, us, si, sg, es (code pays fourni par la source)

Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials

Adem Y. Dawed, Andrea Mari, Andrew Anand Brown, Timothy James McDonald et autres

Background In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacogenomic studies of this inter-individual variation can provide …

gb, it, se, de, dk, nl, us, fr (code pays fourni par la source)

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Andrea Tura, Eleonora Grespan, Christian S. Göbl, Robert Wilhelm Koivula et autres

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants …

it, at, se, gb, de, ch, dk, si, sg, fi, nl, fr (code pays fourni par la source)

A reference map of potential determinants for the human serum metabolome

Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi et autres

il, ca, us, gb, dk, se, it, es, fr, de, nl, ch (code pays fourni par la source)

Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

H. Wilman, Constantinos A. Parisinos, Naeimeh Atabaki‐Pasdar, Matt Kelly et autres

BACKGROUND & AIMS: Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases. …

gb, se, de, fr, it, dk, es, us, nl (code pays fourni par la source)

Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4 ) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1 ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study

Adem Y. Dawed, Kaixin Zhou, Nienke van Leeuwen, Anubha Mahajan et autres

OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin …

gb, nl, se, de, us, fr (code pays fourni par la source)

Text mining of 15 million full-text scientific articles

David Westergaard, Hans‐Henrik Stærfeldt, Christian Tønsberg, Lars Juhl Jensen et autres

Abstract Across academia and industry, text mining has become a popular strategy for keeping up with the rapid growth of the scientific literature. Text mining of the scientific literature has mostly been carried out on collections of abstracts, due to their availability. …

dk (code pays fourni par la source)

GeneWiz browser: An Interactive Tool for Visualizing Sequenced Chromosomes

Peter F. Hallin, Hans‐Henrik Stærfeldt, Eva Rotenberg, Tim T. Binnewies et autres

We present an interactive web application for visualizing genomic data of prokaryotic chromosomes. The tool (GeneWiz browser) allows users to carry out various analyses such as mapping alignments of homologous genes to other genomes, mapping of short sequencing reads to a reference …

dk, ch, us (code pays fourni par la source)

GeneWiz browser: An Interactive Tool for Visualizing Sequenced Chromosomes

Peter F. Hallin, Hans‐Henrik Stærfeldt, Eva Rotenberg, Tim T. Binnewies et autres

We present an interactive web application for visualizing genomic data of prokaryotic chromosomes. The tool (GeneWiz browser) allows users to carry out various analyses such as mapping alignments of homologous genes to other genomes, mapping of short sequencing reads to a reference …

dk, ch, us (code pays fourni par la source)

Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags

Jan Gorodkin, Susanna Cirera, Jakob Hedegaard, Michael J. Gilchrist et autres

BACKGROUND: Knowledge of the structure of gene expression is essential for mammalian transcriptomics research. We analyzed a collection of more than one million porcine expressed sequence tags (ESTs), of which two-thirds were generated in the Sino-Danish Pig Genome Project and one-third are …

ru, gb, dk, cn (code pays fourni par la source)

Origin of replication in circular prokaryotic chromosomes

Peder Worning, Lars Juhl Jensen, Peter F. Hallin, Hans‐Henrik Stærfeldt et autres

To predict origins of replication in prokaryotic chromosomes, we analyse the leading and lagging strands of 200 chromosomes for differences in oligomer composition and show that these correlate strongly with taxonomic grouping, lifestyle and molecular details of the replication process. While all …

us, se, dk, de (code pays fourni par la source)