Accès ouvert
2024
article
OpenAlex
Isabella Friis Jørgensen, Victorine Muse, Alejandro Aguayo‐Orozco, Søren Brunak et autres
Background: Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Considerable clinical research has focused on improving graft survival and an increasing number of kidney recipients die with a functioning graft. There is a need to improve patient …
dk
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Accès ouvert
2023
article
OpenAlex
Victorine Muse, Alejandro Aguayo‐Orozco, Sedrah B. Balaganeshan, Søren Brunak
We identified mortality-, age-, and sex-associated differences in relation to reference intervals (RIs) for laboratory tests in population-wide data from nearly 2 million hospital patients in Denmark and comprising more than 300 million measurements. A low-parameter mathematical wave-based modification method was developed …
dk
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Accès ouvert
2023
erratum
OpenAlex
Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo‐Orozco et autres
In the version of this article initially published, Cristina Leal Rodríguez (Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark) was omitted from the author list. The error has been corrected in the …
dk, it, gb, ch, de, se, nl, fr, fi, us, si, sg, es
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Accès ouvert
2023
article
OpenAlex
Rosa Lundbye Allesøe, Agnete Troen Lundgaard, Ricardo Hernández Medina, Alejandro Aguayo‐Orozco et autres
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based …
dk, it, gb, ch, de, se, nl, fr, fi, us, si, sg, es
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Accès ouvert
2022
preprint
OpenAlex
Victorine Muse, Alejandro Aguayo‐Orozco, Sedrah B. Balaganeshan, Søren Brunak
Abstract We identified mortality-, age-, and sex-associated differences in relation to reference intervals (RI) for laboratory tests in population-wide data from nearly two million hospital patients in Denmark and comprising of more than 300 million measurements. A low-parameter mathematical wave-based modification method …
dk
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Accès ouvert
2021
article
OpenAlex
Sylvia E. Escher, Alejandro Aguayo‐Orozco, Emilio Benfenati, Annette Bitsch et autres
Read-across approaches often remain inconclusive as they do not provide sufficient evidence on a common mode of action across the category members. This read-across case study on thirteen, structurally similar, branched aliphatic carboxylic acids investigates the concept of using human-based new approach …
de, dk, it, gb, nl, es, ch, at, fr, se, us
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Accès ouvert
2021
article
OpenAlex
Alejandro Aguayo‐Orozco, Amalie Dahl Haue, Isabella Friis Jørgensen, David Westergaard et autres
Abstract It is unknown how sequential drug patterns convey information on a patient’s health status and treatment guidelines rarely account for this. Drug-agnostic longitudinal analyses of prescription trajectories in a population-wide setting are needed. In this cohort study, we used 24 years …
dk
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Accès ouvert
2021
article
OpenAlex
Fatima A. H. Al-Jaberi, Martin Kongsbak‐Wismann, Alejandro Aguayo‐Orozco, Nicolai Krogh et autres
The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Here, we describe a new point mutation in the DNA-binding domain of the VDR and its consequences for 1,25(OH)2D3 signaling in …
dk
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Accès ouvert
2020
article
OpenAlex
Alejandro Aguayo‐Orozco, Søren Brunak, Olivier Taboureau
Currently, computational tools able to predict drug-induced liver injury (DILI) based on gene expression data from in vitro assays remain a challenge. Here we introduce a Qualitative Gene expression Activity Relationship (QGexAR) approach to assess the risk of DILI for any chemical. …
dk, fr
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Accès ouvert
2020
article
OpenAlex
Troels Siggaard, Roc Reguant, Isabella Friis Jørgensen, Amalie Dahl Haue et autres
We present the Danish Disease Trajectory Browser (DTB), a tool for exploring almost 25 years of data from the Danish National Patient Register. In the dataset comprising 7.2 million patients and 122 million admissions, users can identify diagnosis pairs with statistically significant …
dk, us
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Accès ouvert
2020
article
OpenAlex
Isabella Friis Jørgensen, Alejandro Aguayo‐Orozco, Mette Lademann, Søren Brunak
INTRODUCTION: Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization. METHODS: We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and …
dk
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Accès ouvert
2019
article
OpenAlex
Kim T. Tran, Jakob S. Pallesen, Sara M. Ø. Solbak, Dilip Narayanan et autres
Inhibiting the protein-protein interaction (PPI) between the transcription factor Nrf2 and its repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in diseases, including central nervous system (CNS) disorders. Numerous non-covalent small-molecule Keap1-Nrf2 PPI inhibitors have been reported …
dk, fr
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