Naeimeh Atabaki‐Pasdar

Energy Conservation Drives Adaptive Specialization Through Fine-tuned Organizations

Teresa Femenía, Naeimeh Atabaki‐Pasdar, Suvi Linna-Kuosmanen, Kevin Grove et autres

Abstract Energy conservation is at the basis of evolutionary optimization in living systems. Yet, how cells maintain function during metabolic stress while preserving adaptive capacity remains unclear. Here, we use a functional genomics approach to identify metabolic human accelerated regions (mHARs) genomic …

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Impact of sample size and tissue relevance on T2D gene identification

David Davtian, T Dupuis, D Mansour Aly, Naeimeh Atabaki‐Pasdar et autres

Abstract Identification of genes and proteins mediating the activity of GWAS variants requires molecular data from disease relevant tissues, but these may be difficult to collect. Using multiple gene expression reference datasets and GWAS summary statistics for T2D we identified 1,818 unique …

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Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes

Kieran Smith, Guy Taylor, Wouter Peeters, Mark Walker et autres

Abstract Aims/hypothesis The temporal suppression of insulin clearance after glucose ingestion is a key determinant of glucose tolerance for people without type 2 diabetes. Whether similar adaptations are observed after the ingestion of a mixed-macronutrient meal is unclear. Methods In a secondary …

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Correction: Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Pascal M. Mutie, Hugo Pomares‐Millan, Naeimeh Atabaki‐Pasdar, Daniel Coral et autres

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A precision medicine approach to coronary artery disease risk prediction and mitigation in people with type 2 diabetes

Paul W. Franks, Daniel Coral, Juan Fernández‐Tajes, Marie Pigeyre et autres

Abstract Type 2 diabetes (T2D) predisposes to cardiovascular disease (CVD), but it is still unclear why some individuals with T2D are at disproportionately higher or lower risk. In this study, we employed a genetic stratification method to investigate the main clinical features …

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Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Andrew Brown, Juan Fernández‐Tajes, Mun‐Gwan Hong, Caroline Brorsson et autres

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple …

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A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Daniel Coral, Juan Fernández‐Tajes, Neli Tsereteli, Hugo Pomares‐Millan et autres

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions and the mechanisms of action are poorly defined. Here we show a genetic-driven approach defining two obesity profiles that convey highly concordant and …

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Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Pascal M. Mutie, Hugo Pomares‐Millan, Naeimeh Atabaki‐Pasdar, Daniel Coral et autres

Abstract Aims/hypothesis Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiometabolic outcomes, which may not be the case. In this …

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Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality

Hugo Pomares‐Millan, Alaitz Poveda, Naeimeh Atabaki‐Pasdar, Ingegerd Johansson et autres

who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; …

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Subtyping of obesity and type 2 diabetes using genetic discordance: a phenome-wide comparative analysis

Daniel Coral, Juan Fernández Tajes, Neli Tsereteli, Giuseppe N. Giordano et autres

Abstract Obesity and type 2 diabetes are causally related, yet the underlying mechanisms are poorly defined. We aimed to subclassify obesity into etiological subtypes using a genetic-driven agnostic approach. Genetic instruments for body mass index and type 2 diabetes were classified into …

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Estimating the Direct Effect between Dietary Macronutrients and Cardiometabolic Disease, Accounting for Mediation by Adiposity and Physical Activity

Hugo Pomares‐Millan, Naeimeh Atabaki‐Pasdar, Daniel Coral, Ingegerd Johansson et autres

Assessing the causal effects of individual dietary macronutrients and cardiometabolic disease is challenging because distinguish direct effects from those mediated or confounded by other factors is difficult. To estimate these effects, intake of protein, carbohydrate, sugar, fat, and its subtypes were obtained …

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Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

Naeimeh Atabaki‐Pasdar, Hugo Pomares‐Millan, Robert W. Koivula, Andrea Tura et autres

ABSTRACT Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of the putative causal pathways linking …

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