Accès ouvert
2023
article
OpenAlex
Chriselda G. Fedyk, George M. Shahin, Ronnie Hill
BACKGROUND: The U.S. Department of Defense (DoD) collects blood from volunteer DoD donors in U.S. Food and Drug Administration (FDA)-regulated centers, and from emergency donor panels in overseas operations. Emerging infectious diseases could reduce DoD access to blood products. In August 2016, …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Heather F. Pidcoke, Wilfred P. Delacruz, Maryanne C. S. Herzig, Beverly S. Schaffer et autres
A perfluorocarbon (PFC) investigated for treatment of traumatic brain injury (TBI) delivers oxygen to support brain function, but causes transient thrombocytopenia. TBI can cause acute inflammation with resulting thrombocytopenia; an interaction between the PFC effects and TBI inflammation might exacerbate thrombocytopenia. Therefore, …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Morten Zaar, Maryanne C. S. Herzig, Chriselda G. Fedyk, Robbie K. Montgomery et autres
BACKGROUND: To study central hypovolemia in humans, lower body negative pressure (LBNP) is a recognized alternative to blood removal (HEM). While LBNP mimics the cardiovascular responses of HEM in baboons, similarities in hemostatic responses to LBNP and HEM remain unknown in this …
us, fr
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Maryanne C. S. Herzig, Chriselda G. Fedyk, Robbie K. Montgomery, Beverly S. Schaffer et autres
BACKGROUND: This study evaluated blood components processed by the platelet rich plasma (PRP) method from fresh whole blood (FWB) treated with a pathogen reduction technology (PRT). The effects of storage temperature on PRT treated platelet concentrates (PCs) were also examined. STUDY DESIGN …
us
(code pays fourni par la source)
2019
conference-abstract
OpenAlex
Maryanne C. S. Herzig, Morten Zaar, Chriselda G. Fedyk, Bijaya Kumar Parida et autres
Background: Lower body negative pressure (LBNP) has been established in human studies as an alternative method to blood removal (HEM) to study central hypovolemia. In a baboon model, LBNP also mimics the cardiovascular response of HEM. Hemostatic responses, including platelet activation, coagulation …
us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Jared A. Cohen, Thomas G. Scorer, Zachary Wright, Ian J. Stewart et autres
BACKGROUND: Hemorrhage is the leading cause of preventable trauma-related mortality and is frequently aggravated by acute traumatic coagulopathy (ATC). Viscoelastic tests such as rotational thromboelastometry (ROTEM) may improve identification and management of ATC. This study aimed to prospectively evaluate changes in ROTEM …
it, gb, us
(code pays fourni par la source)
2016
article
OpenAlex
Thomas A. Mitchell, Maryanne C. S. Herzig, Chriselda G. Fedyk, Marc A. Salhanick et autres
OBJECTIVES: Autotransfusion of shed blood from traumatic hemothorax is an attractive option for resuscitation of trauma patients in austere environments. However, previous analyses revealed that shed hemothorax (HX) blood is defibrinated, thrombocytopenic, and contains elevated levels of D-dimer. Mixing studies with normal …
us, fr
(code pays fourni par la source)
2016
article
OpenAlex
Marc A. Salhanick, Valere G. Sams, Heather F. Pidcoke, Chriselda G. Fedyk et autres
PURPOSE: The autotransfusion of unwashed (or unprocessed) shed hemothorax blood (USHB) in trauma patients is widely assumed to be beneficial; however, the inflammatory potential of shed pleural blood has not been thoroughly studied. Since previous studies have documented marked changes in coagulation …
us, es
(code pays fourni par la source)
2015
article
OpenAlex
Aaron T. Henderson, Thomas A. Mitchell, Maryanne C. S. Herzig, Chriselda G. Fedyk
Abstract Introduction Hemostatic resuscitation in combat casualty care presents unique challenges not typically encountered in metropolitan areas. Fresh whole blood and blood components are considered preferable to crystalloid or colloid solutions, but availability may be limited in austere wartime environments. Autologous shed …
us
(code pays fourni par la source)
Accès ouvert
2015
article
OpenAlex
Heather F. Pidcoke, Claire Larson Isbell, Maryanne C. S. Herzig, Chriselda G. Fedyk et autres
BACKGROUND: Many military and civilian centers have shifted to a damage-control resuscitation approach, focused on providing oxygen-carrying capacity while simultaneously mitigating coagulopathy with a balanced ratio of platelets and plasma to red blood cells. It is unclear to what degree this strategy …
us
(code pays fourni par la source)
Accès ouvert
2014
article
OpenAlex
Morten Zaar, Chriselda G. Fedyk, Heather F. Pidcoke, Michael R. Scherer et autres
Central hypovolemia elevates hemostatic activity which is essential for preventing exsanguination after trauma, but platelet activation to central hypovolemia has not been described. We hypothesized that central hypovolemia induced by lower body negative pressure (LBNP) activates platelets. Eight healthy subjects were exposed …
us
(code pays fourni par la source)
2014
article
OpenAlex
Heather F. Pidcoke, Chriselda G. Fedyk, Robbie K. Montgomery, Carmen Hinojosa‐Laborde et autres
Abstract Up to 50% of preventable trauma deaths are due to truncal hemorrhage resulting in cardiovascular collapse. Lower body negative pressure (LBNP) causes central hypovolemia in humans, resulting in coagulation changes, platelet activation, and fibrinolysis. The model allows investigators to study impending …
us
(code pays fourni par la source)