Thomas Scorer

Serum‐derived albumin as a cryoprotective agent for the long‐term storage of red blood cells: A preliminary examination

Thomas Bailey‐Schmidt, Christine Saunders, Chloë George, Thomas Scorer et autres

BACKGROUND: Cryopreservation extends the shelf life of red blood cells (RBC) from weeks to years, offering major advantages for blood banking logistics, especially in remote environments. However, current glycerol-based methods, though effective, are limited in scope due to complex post-thaw washing and …

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Impact of a rapid blood warmer on the quality and function of cold‐stored platelets

Sarah Goatson, Jamie Nash, Christine Saunders, Nicola Pearce et autres

BACKGROUND AND OBJECTIVES: Pre-hospital critical care faces challenges in carrying platelet concentrates (PC). Cold-stored platelets (CSP) may offer improved haemostatic function over room temperature platelets. Rapid warming of blood products is crucial for hypothermic trauma patients. This study evaluates whether the°M Warmer …

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Three buffy coat platelet concentrates: Use of data modelling to make more with less

Michael Cahillane, Nicola Pearce, Christine Saunders, Nicole Polidano et autres

Abstract Background and Objectives The Welsh Blood Service (WBS) produces pooled platelet concentrates from four buffy coats (4BC‐PC), achieving consistently high platelet yields exceeding the UK specification. Three buffy coat platelet concentrates (3BC‐PC) offer the potential for improved supply chain resilience and …

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Exploring tricine as a novel red cell cryopreservative: Lessons and future directions

Thomas Bailey‐Schmidt, Christine Saunders, Chloë George, Thomas Scorer et autres

BACKGROUND AND OBJECTIVES: Cryopreservation allows for storage of red blood cells (RBCs) beyond the standard 35-day period. Current glycerol-based methods are labour-intensive and scale-limited in application. Tricine has been identified as a potential alternative cryoprotectant (CPA), demonstrating efficacy in sheep RBC. This …

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What is the risk of transfusing group O RhD-positive red blood cells to female service personnel of childbearing potential?

Mark H. Yazer, Thomas Scorer, D McConnell, Jake Gluyas-Harris

The traditional approach to resuscitating injured women of childbearing potential (WCBP) with an unknown RhD type is to transfuse RhD-negative blood products. This is to prevent alloimmunisation to the RhD antigen and ultimately prevent haemolytic disease of the fetus and newborn (HDFN) …

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Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review

Justin Lu, Keyvan Karkouti, Miki Peer, Marina Englesakis et autres

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OC 23.5 National External Quality Assessment Scheme (NEQAS BC) and Welsh Blood Service (WBS) use Cold-Stored Platelets for External Quality Assessment (EQA) Scheme for Light Transmission Aggregometry (LTA)

Christopher Reilly‐Stitt, Ian Jennings, Steve Kitchen, I. Walker et autres

Background: RNA-binding proteins (RBPs) are central for gene expression by controlling the RNA fate from birth to decay.Various disorders arising from perturbations of RNA-protein interactions document their critical function.Perturbations of posttranscriptional control can cause bleeding (1) and thrombotic disorders (2).While an unbiased …

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TEG PlateletMapping assay results may be misleading in the presence of cold stored platelets

Thomas Scorer, Lucy Fitzgibbon, Riyaad Aungraheeta, Umang Sharma et autres

BACKGROUND Viscoelastic tests (VETs) are used widely to monitor hemostasis in settings such as cardiac surgery. There has also been renewed interest in cold stored platelets (CSPs) to manage bleeding in this setting. CSPs are reported to have altered hemostatic properties compared …

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Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas Scorer, Kristin M. Reddoch‐Cardenas, Kimberly A. Thomas, Philip C. Spinella

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Manufacturing variables and hemostatic function of cold‐stored platelets: a systematic review of the literature

Thomas Scorer, A. F. Williams, Kristin M. Reddoch‐Cardenas, Andrew Mumford

[No Abstract]

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A prospective evaluation of thromboelastometry (ROTEM) to identify acute traumatic coagulopathy and predict massive transfusion in military trauma patients in Afghanistan

Jared Cohen, Thomas Scorer, Zachary Wright, Ian J. Stewart et autres

BACKGROUND: Hemorrhage is the leading cause of preventable trauma-related mortality and is frequently aggravated by acute traumatic coagulopathy (ATC). Viscoelastic tests such as rotational thromboelastometry (ROTEM) may improve identification and management of ATC. This study aimed to prospectively evaluate changes in ROTEM …

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Ticagrelor Induced Platelet Dysfunction Can be Assessed Under Shear Conditions and Correction By Platelets Is Influenced By Storage Temperature

Thomas Scorer, Umang Sharma, Grantham C. Peltier, Colby S. McIntosh et autres

Abstract Introduction: The use of antiplatelet (anti-PLT) drugs for prophylaxis and treatment of cardiovascular disease continues to rise. A significant problem with these medications is increased bleeding, which can be life threatening. Strategies to manage bleeding whilst on anti-PLT medication are limited …

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