Robert A.M. Op den Buijsch

Review article: the prevalence and clinical relevance of cytochrome P450 polymorphisms

Petal A H M Wijnen, Robert A.M. Op den Buijsch, Marjolein Drent, P. M. J. C. KUIPERS et autres

BACKGROUND: Most drugs currently used in clinical practice are effective in only 25% to 60% of patients, while adverse drug reactions (ADRs) as a consequence of treatment are estimated to cost billions of US dollars and tens of thousands of deaths. AIM: …

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Genotyping with a dried blood spot method: A useful technique for application in pharmacogenetics

Petal A H M Wijnen, Robert A.M. Op den Buijsch, Jacques van der Heijden, K. Hoogtanders et autres

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Evaluation of limited sampling strategies for tacrolimus

Robert A.M. Op den Buijsch, Afke van de Plas, Leo M. Stolk, Maarten H. L. Christiaans et autres

OBJECTIVE: In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC0-12) is limited. The aim of this study was …

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Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate‐binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms

Robert A.M. Op den Buijsch, Maarten H. L. Christiaans, Leo M. Stolk, Johan E. de Vries et autres

Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range and its pharmacokinetic variability complicates its daily dose assessment. P-glycoprotein (P-gp), encoded by the adenosine triphosphate-binding cassette B1 (ABCB1) and the cytochrome (CYP) 3A4 and 3A5 enzymes appears to play …

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Genotyping of the PXR A11156C polymorphism with locked nucleic acid containing fluorogenic probes

Robert A.M. Op den Buijsch, Jan E. De Vries, Wil J. G. Loots, Olfert Landt et autres

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Capillary electrophoretic detection in apolipoprotein E genotyping

Otto Bekers, Robert A.M. Op den Buijsch, Johan E. de Vries, Petal A H M Wijnen et autres

We describe the application of capillary electrophoresis to detect DNA fragments, obtained after amplifying a part of the apolipoprotein E (apoE) gene with polymerase chain reaction (PCR). Compared to conventional agarose slab gel electrophoresis (AGE), CE appears the method of choice with …

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