Afke van de Plas

Targeting what matters: A quasi-experimental controlled before-and-after study on targeted double checks in parenteral medication administration

Afke van de Plas, Fatma Karapinar-Çarkit, Janne Jacobs, Roger Rennenberg et autres

BACKGROUND: Parenteral medication administration is associated with a substantial risk of medication errors. Independent double-checking by two nurses is widely mandated to reduce this risk; however, evidence is lacking, compliance is inconsistent, and the procedure is time-consuming. Medication safety organisations increasingly recommend …

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Adapting, implementing and evaluating a navigation intervention for older people with cancer and their family caregivers in six countries in Europe: the Horizon Europe-funded EU NAVIGATE project

Rose Mara Miranda, Tinne Smets, Lara Pivodic, Kenneth Chambaere et autres

Background: Navigation interventions could support, educate and empower older people with cancer and/or their family caregivers by addressing barriers and ensuring timely access to needed services and resources throughout the continuum of supportive, palliative and end-of-life care. Objectives: European Union (EU) NAVIGATE …

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Implementing a new antibiotic allergy protocol in clinical practice: well-trusted but not used

Priscilla Hanssen, Chris M. G. Nieuwhof, S van Mens, Afke van de Plas et autres

BACKGROUND: Suboptimal antibiotic prescriptions in patients with an antibiotic allergy label lead to increased incidence of adverse events and antimicrobial resistance (AMR). An antibiotic allergy protocol was developed in a Dutch academic hospital guiding optimal and safe antibiotic use in potentially penicillin-allergic …

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Experiences with Lean Six Sigma as improvement strategy to reduce parenteral medication administration errors and associated potential risk of harm

Afke van de Plas, Mariëlle Slikkerveer, Saskia Hoen, Rick Schrijnemakers et autres

In this controlled before-after study the effect of improvements, derived from Lean Six Sigma strategy, on parenteral medication administration errors and the potential risk of harm was determined. During baseline measurement, on control versus intervention ward, at least one administration error occurred …

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Allergie bekend, toch anafylactische shock: Overgevoeligheid stond op medicatieoverzicht, maar dat is niet geraadpleegd

Afke van de Plas, D.A. Opstelten

Parenteral medication preparation by pharmacy technicians on the ward improves medication safety

Afke van de Plas, C. Smits, W. B. J. Mens, Redmer van Leeuwen et autres

Background Preparation of parenteral medications is associated with considerable risk that is medication errors and risk of microbiological contamination. In Dutch hospitals parenteral medications are commonly prepared on the ward by nursing staff. In a pilot in the Maastricht University Medical Centre, …

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Preparation and physicochemical evaluation of a new tacrolimus tablet formulation for sublingual administration

Parinda Srinarong, Bao Tung Pham, Maru Holen, Afke van de Plas et autres

The aim of this study was to develop a new fast-disintegrating tablet formulation containing 1 mg tacrolimus for sublingual application. First, solid dispersions containing tacrolimus (2.5%, 5% and 10% w/w) incorporated in Ac-Di-Sol(®) and carriers (inulin 1.8 kDa and 4 kDa, and …

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A pilot study on sublingual administration of tacrolimus

Afke van de Plas, J. Dackus, Maarten H. L. Christiaans, Leo M. Stolk et autres

The immunosuppressant tacrolimus has a narrow therapeutic index and a high variability of its pharmacokinetics, e.g. oral bioavailability of tacrolimus is very variable [mean 25% (4–93%)]. Reams et al. showed that sublingual administration of tacrolimus results in therapeutic blood levels in patients …

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A PILOT STUDY ON SUBLINGUAL AND RECTAL ADMINISTRATION OF TACROLIMUS

Afke van de Plas, J. Dackus, Maarten H. L. Christiaans, Leo M. Stolk et autres

Van de Plas, A; Dackus, J; Christiaans, M; Stolk, L; Neef, K; Van Hooff, J Author Information

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Factors influencing bar-code verification by nurses during medication administration in a Dutch hospital

Hein A. W. van Onzenoort, Afke van de Plas, Alfons G.H. Kessels, Nicole M.L. Veldhorst-Janssen et autres

PURPOSE: Factors influencing the bar-code verification by nurses during medication administration in a Dutch hospital were studied. SUMMARY: The use of bar-code verification during medication administration in five medical departments was recorded daily for three weeks. These data were collected via electronic …

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Dried blood spot measurement: application in tacrolimus monitoring using limited sampling strategy and abbreviated AUC estimation

Chi Yuen Cheung, Jaques van der Heijden, K. Hoogtanders, Maarten H. L. Christiaans et autres

Dried blood spot (DBS) sampling and high-performance liquid chromatography tandem-mass spectrometry have been developed in monitoring tacrolimus levels. Our center favors the use of limited sampling strategy and abbreviated formula to estimate the area under concentration-time curve (AUC(0-12)). However, it is inconvenient …

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Evaluation of limited sampling strategies for tacrolimus

Robert A.M. Op den Buijsch, Afke van de Plas, Leo M. Stolk, Maarten H. L. Christiaans et autres

OBJECTIVE: In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC0-12) is limited. The aim of this study was …

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