Ron W.F. de Bruin

Performance-based frailty tools capture distinct risk phenotypes in kidney transplant candidates: A comparative analysis of the FRAIL scale and short physical performance battery

Rucháma Verhoeff, Frank E. Hullekes, E Jaffe, Jennie L. Cataldo et autres

Frailty predicts adverse outcomes in kidney transplant candidates, but it remains unclear whether different frailty tools identify the same or distinct at-risk patients. In this retrospective cohort study, 953 kidney transplant candidates listed between 2018 and 2022 underwent frailty assessment using both …

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Machine Learning-Driven Assessment of Early Graft Function in Living Donor Kidney Transplantation Using Intraoperative Laser Speckle Contrast Imaging

Yitian Fang, You Li, Hendrikus J. A. N. Kimenai, Miao‐Ping Chien et autres

ABSTRACT Background Although living donor kidney transplantation (LDKT) generally achieves excellent outcomes, 5–12% of recipients experience early graft dysfunction, which is associated with poorer long-term survival. Current predictive tools rely mainly on clinical parameters and lack intraoperative applicability. Laser speckle contrast imaging …

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Impact of Donor and Recipient Sex on Long‐Term Outcomes Following Living Donor Kidney Transplantation: A Retrospective Dual‐Center Study

Yitian Fang, Lisa B. Westenberg, Julie J. M. Hamm, Jacqueline van de Wetering et autres

BACKGROUND: The impact of donor and recipient sex on living donor kidney transplantation (LDKT) remains debated. This study investigates the impact of donor-recipient sex combinations on long-term transplant outcomes. METHODS: A dual-center retrospective study was conducted at Erasmus Medical Center (EMC) and …

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Outcomes of En Bloc Kidney Transplants from Small Deceased Pediatric Donors to Adult Recipients: A Single-Center Experience

Haichen Yan, Judith Kal-van Gestel, Yitian Fang, Jacqueline van de Wetering et autres

Introduction The shortage of donor grafts for kidney transplantation remains a critical challenge. En bloc kidney transplantation (EBKT) from small deceased pediatric donors can potentially expand the donor pool. This study aimed to investigate the safety of pediatric-donor EBKT in adults compared …

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SGLT2 Inhibitors and GLP-1 Receptor Agonists in Kidney Transplantation: A Systematic Review and Meta-Analysis

Sul A Lee, Rucháma Verhoeff, Frank Hullekes, Panupong Hansrivijit et autres

BACKGROUND: Kidney transplant (KT) recipients experience high rates of cardiovascular disease, allograft dysfunction, and diabetes, negatively impacting long-term outcomes. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide cardiovascular and kidney benefits in non-KT recipients, but evidence in KT …

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Closure of Mesenteric Defects during Roux-en-Y Gastric Bypass Fails to Reduce Internal Herniation

Annick E Taselaar, Ron W.F. de Bruin, T. Martijn Kuijper, Erwin van der Harst et autres

INTRODUCTION: The rising obesity rates have led to an increased demand for bariatric surgery, particularly laparoscopic Roux-en-Y gastric bypass (LRYGB). While effective, LRYGB carries risks such as internal herniation (IH). This study evaluates the impact of routinely closing mesenteric defects (MD) during …

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Effect of donor body weight on en bloc pediatric kidney transplantation in adults: A systematic review and meta-analysis

Haichen Yan, Yitian Fang, Jacqueline van de Wetering, Hendrikus J. A. N. Kimenai et autres

BACKGROUND: The shortage of donor grafts for kidney transplantation remains a critical challenge. En bloc kidney transplantation (EBKT) using small deceased pediatric donors has the potential to expand the donor pool. This review aimed to investigate the outcomes of pediatric-donor EBKT in …

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Enhancing Kidney Quality Assessment: Power Doppler During Normothermic Machine Perfusion

Yitian Fang, Anton V. Nikolaev, Jeroen Essers, Gisela Ambagtsheer et autres

ABSTRACT Objectives Marginal donor kidneys are increasingly used for transplantation to overcome organ shortage. This study aims to investigate the additional value of Power Doppler (PD) imaging in kidney quality assessment during normothermic machine perfusion (NMP). Methods Porcine kidneys ( n = …

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Bariatric surgery reverses morbid obesity-induced changes in the composition of circulating immune cells—a prospective cohort study

A. E. Taselaar, Leontine H. Wijngaarden, René A. Klaassen, Erwin van der Harst et autres

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Enhancing kidney quality assessment: Power Doppler during normothermic machine perfusion

Yitian Fang, Anton V. Nikolaev, Jeroen Essers, Gisela Ambagtsheer et autres

Objectives: Marginal donor kidneys are increasingly used for transplantation to overcome organ shortage. This study aims to investigate the additional value of Power Doppler (PD) imaging in kidney quality assessment during normothermic machine perfusion (NMP). Methods: Porcine kidneys (n=22) retrieved from a …

Physiological arterial pressure improves renal performance during normothermic machine perfusion in a porcine kidney DCD model

Yitian Fang, Gisela Ambagtsheer, Lin Xia, Marian C. Clahsen‐van Groningen et autres

Background Normothermic machine perfusion (NMP) provides a platform for kidney quality assessment. Donation after circulatory death (DCD) donor kidneys are associated with great ischemic injury and high intrarenal resistance (IRR). This experimental study aims to investigate the impact of different perfusion pressures …

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Treatment of Renal Artery Aneurysm by ex situ Repair and Autotransplantation: A Nationwide Cohort Study

Yitian Fang, Hendrikus J. A. N. Kimenai, Ron W.F. de Bruin, Dorottya K. de Vries et autres

INTRODUCTION: Renal artery aneurysm (RAA) is a rare vascular disease with a mortality rate of up to 80% upon rupture. This study aimed to investigate the safety and efficacy of ex situ repair and autotransplantation for endovascularly untreatable RAA. METHODS: A retrospective …

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