Hui-Kuan Lin

Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

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Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting

Bo‐Syong Pan, Che-Chia Hsu, Hsin‐En Wu, Yuan-Ru Chen et autres

Glucose metabolism is a pivotal hub for cellular energy production and the generation of building blocks that support cell growth, survival, and differentiation. Cancer cells undergo metabolic reprogramming to sustain rapid proliferation, survive in harsh microenvironments, and resist therapies. Beyond producing energy …

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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

BACKGROUND: Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on …

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Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer

Shin-Chih Lin, Ya-Chuan Tsai, Yinglan Chen, Hui-Kuan Lin et autres

AIMS: The recent approval of enzalutamide for metastatic castration-sensitive prostate cancer underscores its growing clinical significance, raising concerns about emerging resistance and limited treatment options. While the reactivation of the androgen receptor (AR) and other genes plays a role in enzalutamide resistance, …

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The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

Fei Han, Chien‐Feng Li, Zhen Cai, Xian Zhang et autres

PI3K/Akt signaling is activated in cancers and governs tumor initiation and progression, but how Akt is activated under diverse stresses is poorly understood. Here we identify AMPK as an essential regulator for Akt activation by various stresses. Surprisingly, AMPK is also activated …

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H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

Xian Zhang, Binkui Li, Abdol Hossein Rezaeian, Xiaohong Xu et autres

Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 …

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Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

Lu Chen, Lei Du‐Cuny, Sylvestor A. Moses, Sabrina N. Dumas et autres

The Grb2-associated binding protein 1 (GAB1) integrates signals from different signaling pathways and is over-expressed in many cancers, therefore representing a new therapeutic target. In the present study, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treatment. …

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Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

Chia‐Hsin Chan, Szu-Wei Lee, Jing Wang, Hui-Kuan Lin

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through …

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