Chia‐Hsin Chan

Nonmonotone invasion landscape by noise-aware control of metastasis activator levels

Yiming Wan, Joseph Cohen, Mariola Szenk, Kevin S. Farquhar et autres

A major pharmacological assumption is that lowering disease-promoting protein levels is generally beneficial. For example, inhibiting metastasis activator BACH1 is proposed to decrease cancer metastases. Testing such assumptions requires approaches to measure disease phenotypes while precisely adjusting disease-promoting protein levels. Here we …

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Supplementary Table 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim, Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee et autres

PDF file - 22KB, Primer and shRNA sequences.

Supplementary Figure 1 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim, Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee et autres

PDF file - 155KB, UTX knockdown had no effect on cell migration, whereas MLL4 depletion moderately decreased cell migration.

Supplementary Figure 4 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim, Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee et autres

PDF file - 48KB, Two different MLL4 antibodies confirmed that MLL4 is recruited to MMP-9, MMP-11, and Six1 genes.

Supplementary Figure 5 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim, Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee et autres

PDF file - 33KB, UTX or MLL4 knockdown did not have any obvious effect on total cellular levels of H3K27me3 and H3K4me3.

Supplementary Figure 6 from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Jae-Hwan Kim, Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee et autres

PDF file - 57KB, MLL4 Knockdown decreased UTX mRNA and protein levels, but UTX knockdown did not have any significant effect on MLL4 mRNA levels.

Data from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai‐Yu Chen, Pu‐Yeh Kan et autres

Abstract Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also …

Data from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai‐Yu Chen, Pu‐Yeh Kan et autres

Abstract Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also …

Supplemental Table S3 from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai‐Yu Chen, Pu‐Yeh Kan et autres

Top 150 genes up-regulated by JARID1D knockdown in DU145 cells.

Supplemental Table S1 from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai‐Yu Chen, Pu‐Yeh Kan et autres

RT-PCR Primer Sequences.

Data from UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

Amrish Sharma, Shilpa S. Dhar, Sung-Hun Lee, Bingnan Gu et autres

Abstract Histone methyltransferases and demethylases reversibly modulate histone lysine methylation, which is considered a key epigenetic mark associated with gene regulation. Recently, aberrant regulation of gene expression by histone methylation modifiers has emerged as an important mechanism for tumorigenesis. However, it remains …

Supplemental Table S2 from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis

Na Li, Shilpa S. Dhar, Tsai‐Yu Chen, Pu‐Yeh Kan et autres

ChiP primer sequences.