Accès ouvert
2024
article
OpenAlex
Felix F. Krause, Kira Mangold, Anna-Lena Ruppert, Hanna Leister et autres
Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal Clostridium sporogenes possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate …
de
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Accès ouvert
2024
article
OpenAlex
Maik Luu, Felix F. Krause, Heide Monning, Anne Wempe et autres
-mediated expression of Blimp-1, a transcription regulator of IL-10. Surprisingly, this effect was counteracted by the NF-κB transcription factor c-Rel. A functional screen for intestinal bacterial species identified the commensal Clostridium sporogenes, secreting high amounts of short-chain fatty acids (SCFAs) and branched-chain …
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Accès ouvert
2024
preprint
OpenAlex
Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz et autres
The microbiome is a complex host factor and key determinant of the outcome of antibody-based and cellular immunotherapy. Its postbiotics are a blend of soluble commensal byproducts that are released into the host environment and have been associated with the regulation of …
de, ca, es, lt, us, at
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Felix F. Krause, Kira Mangold, Anna-Lena Ruppert, Hanna Leister et autres
Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal Clostridium sporogenes possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate …