Giuseppe Jannuzzi

Spuriously elevated estradiol due to immunoassay interference in the workup of a suspected ovarian tumor: Diagnostic pitfalls and laboratory workflow recommendations

Giovanni Lupoli, Carmela Polito, Giuseppe Jannuzzi, Mariano Fiorenza et autres

BACKGROUND: Falsely elevated estradiol levels due to analytical interference are rare but clinically relevant diagnostic pitfalls, particularly when results suggest an estrogen-producing tumor. CASE PRESENTATION: We report the case of a 51-year-old woman with markedly increased estradiol concentrations inconsistent with her clinical …

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Uncovering hidden HCV infections in adults over 55: reflex testing and insights for opportunistic screening in a tertiary care setting

Emma Montella, Rita Nocerino, Simona Del Sorbo, Stefano Brusa et autres

BACKGROUND: Hepatitis C virus (HCV) remains a global public health concern. Despite the availability of direct-acting antivirals (DAAs), many infections remain undiagnosed—particularly in older adults excluded from national screening programs. This study aimed to assess the prevalence of unrecognized HCV infections in …

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Comparative analysis of three thyroglobulin immunoassays: analytical performance and clinical implications

Evelina La Civita, Mariano Fiorenza, Giuseppe Jannuzzi, Rosa Sirica et autres

OBJECTIVES: Serum thyroglobulin (Tg) is a key biomarker in the post-surgical monitoring of differentiated thyroid cancer (DTC). However, inter-assay variability among different immunoassay platforms can impact clinical interpretation, particularly at low Tg concentrations. This study aimed to compare the analytical performance and …

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Comparison Between a New PSA Assay With the Well‐Established Beckman Coulter Immunoassay: A Preliminary Report

Evelina La Civita, Mariano Fiorenza, Giuseppe Jannuzzi, Rosa Sirica et autres

ABSTRACT Prostate‐specific antigen (PSA) is a critical biomarker for prostate cancer (PCa) patient clinical management. In this study, we sought to compare three different immunoassays (CLIA): Beckman Coulter Access Hybritech (PSA‐B) (reference method), Immulite 2000 PSA (PSA‐I) and the newly introduced Atellica …

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Serum (‐2)proPSA/freePSAratio, (‐2)proPSA/freePSA density, prostate health index, and prostate health index density as clues to reveal postoperative clinically significant prostate cancer in men with prostate‐specific antigen 2–10 ng/mL

Matteo Ferro, Felice Crocetto, Evelina La Civita, Mariano Fiorenza et autres

BACKGROUND: There is a strong clinical need to fill the gap of identifying clinically significant prostate cancer (csPCa) in men with prostate-specific antigen (PSA) gray zone values. Promising, but not definitive results have been obtained using PSA derivatives such as prostate health …

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The role of biomarkers in differential diagnosis of neurodegenerative dementias: A case report

Giuseppe Alessio Carbone, Evelina La Civita, Mariano Fiorenza, Valerio Nicolella et autres

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Clinical validation in multiple sclerosis of the lumipulse immunoassay for plasma neurofilament light chain

Mariano Fiorenza, Giuseppina Maria Carbone, Evelina La Civita, G. Felicelli et autres

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Anti‐HDV reflex testing in HBsAg ‐positive subjects: An efficacious strategy to identify HDV infection

Valentina Cossiga, Stefano Brusa, Roberto Montalti, Giuseppe Jannuzzi et autres

BACKGROUND AND AIMS: The prevalence of HDV infection in HBsAg carriers is about 9.9% in Italy. However, the real prevalence is underestimated because the anti-HDV test is not performed routinely in all HBsAg carriers. The aim of this study was to compare …

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A Multicenter Randomized Controlled Trial on the Clinical Impact of Therapeutic Drug Monitoring in Patients with Newly Diagnosed Epilepsy

Giuseppe Jannuzzi, P. Cian, Cinzia Fattore, Giuliana Gatti et autres

PURPOSE: To assess the clinical impact of monitoring serum concentrations of antiepileptic drugs (AEDs) in patients with newly diagnosed epilepsy. METHODS: One-hundred eighty patients with partial or idiopathic generalized nonabsence epilepsy, aged 6 to 65 years, requiring initiation of treatment with carbamazepine …

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