Cinzia Fattore

A prospective randomized crossover trial investigating melatonin versus sleep deprivation for sleep induction in nap electroencephalography

Valentina De Giorgis, Costanza Varesio, Massimiliano Celario, Carlo Alberto Quaranta et autres

OBJECTIVE: Electroencephalography (EEG) plays a fundamental role in the diagnosis and classification of epilepsy, and inducing sleep during EEG can improve patient cooperation and enhance the detection of epileptiform activity. Despite its importance, there is currently no standardized approach for sleep induction …

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Therapeutic Salivary Monitoring of Perampanel in Patients with Epilepsy Using a Volumetric Absorptive Microsampling Technique

Michela Palmisani, Elena Tartara, Cecilie Johannessen Landmark, Francesca Crema et autres

The objective of this study was to validate a novel assay using the volumetric absorptive microsampling (VAMS) technique combined with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the determination of the antiseizure medication perampanel in saliva and its clinical applicability …

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Melatonin versus Sleep Deprivation for Sleep Induction in Nap Electroencephalography: Protocol for a Prospective Randomized Crossover Trial in Children and Young Adults with Epilepsy

Costanza Varesio, Valentina Franco, Ludovica Pasca, Massimiliano Celario et autres

Electroencephalography (EEG) continues to be a pivotal investigation in children with epilepsy, providing diagnostic evidence and supporting syndromic classification. In the pediatric population, electroencephalographic recordings are frequently performed during sleep, since this procedure reduces the number of artifacts and activates epileptiform abnormalities. …

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On-Line Solid Phase Extraction High Performance Liquid Chromatography Method Coupled With Tandem Mass Spectrometry for the Therapeutic Monitoring of Cannabidiol and 7-Hydroxy-cannabidiol in Human Serum and Saliva

Valentina Franco, Michela Palmisani, Roberto Marchiselli, Francesca Crema et autres

Cannabidiol is a novel antiseizure medication approved in Europe and the US for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complex. We describe in this article a new and simple liquid chromatography-mass spectrometry method (LC-MS/MS) for …

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POSB74 Belantamab Mafodotin as the First-in-Class Anti-BCMA Treatment for Relapsed/Refractory Multiple Myeloma: A Budget Impact and Cost-Effectiveness Analysis

MJ Diliberto, Cinzia Fattore, Francesco Paolo Fiorentino, Thibaud Prawitz et autres

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Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial

Jacqueline Palace, Dean M. Wingerchuk, Kazuo Fujihara, Achim Berthele et autres

BACKGROUND: Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury. The PREVENT study demonstrated that the terminal complement inhibitor eculizumab reduces …

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Does screening for adverse effects improve health outcomes in epilepsy?

Valentina Franco, Maria Paola Canevini, Giovambattista De Sarro, Cinzia Fattore et autres

Objective To determine whether systematic screening for adverse effects of antiepileptic drugs (AEDs) reduces toxicity burden and improves health-related quality of life in patients with epilepsy. Methods Consecutive patients with uncontrolled seizures aged ≥16 years and a high Adverse Event Profile (AEP) …

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Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy

Valentina Franco, Giuliana Gatti, Iolanda Mazzucchelli, Roberto Marchiselli et autres

Abstract The assay of saliva samples provides a valuable alternative to the use of blood samples for therapeutic drug monitoring (TDM), at least for certain categories of patients. To determine the feasibility of using saliva sampling for the TDM of rufinamide, we …

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Psychosocial impact of sport activity in neuromuscular disorders

Gian Luca Vita, Claudia Stancanelli, Stefania La Foresta, Cristina Faraone et autres

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Determination of Perampanel in Dried Plasma Spots: Applicability to Therapeutic Drug Monitoring

Valentina Franco, Katia Baruffi, Roberto Marchiselli, Francesca Crema et autres

BACKGROUND: Although therapeutic drug monitoring of antiepileptic drugs is typically based on the analysis of plasma samples, alternative matrices, such as dried plasma spots (DPSs), may offer specific advantages. The aims of this work were to (1) develop and validate a bioanalytical …

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A simple and rapid HPLC‐UV method for the determination of retigabine in human plasma

Valentina Franco, Katia Baruffi, Giuliana Gatti, Roberto Marchiselli et autres

Abstract A simple and rapid high‐performance liquid chromatographic method with ultraviolet detection was developed for the quantitative determination of retigabine, known also as ezogabine, in human plasma. The assay uses a simple solid‐phase extraction for sample preparation and direct injection of the …

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Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma

Valentina Franco, Roberto Marchiselli, Cinzia Fattore, Elena Tartara et autres

BACKGROUND: Perampanel, a new specific non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist, has been recently approved in the United States and the European Union for the adjunctive treatment of focal seizures and primary generalized tonic-clonic seizures associated with idiopathic generalized epilepsy. A positive relationship …

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