Rosa Sirica

PHI for adverse pathology and PHI density for upgrading: two complementary predictors in localized prostate cancer

Daniela Terracciano, Francesco Pellegrino, Mariano Fiorenza, Carmela Polito et autres

Abstract Background The Prostate Health Index (PHI) has emerged as a promising biomarker for improving prostate cancer (PCa) detection. However, its role in predicting pathological aggressiveness at radical prostatectomy (RP) requires further elucidation. We aimed to assess the ability of PHI and …

Real-world Roche Elecsys® and Fujirebio Lumipulse® inter-platform comparability and clinical validation of plasma neurofilament light chain in multiple sclerosis

Vincenzo Criscuolo, Valerio Nicolella, Carmela Polito, Rosa Sirica et autres

Abstract Background Neurofilament light chain (NfL) reflects neuro-axonal injury in multiple sclerosis (MS), but method-dependent bias limits interchangeability across automated platforms. We assessed agreement between Roche Elecsys ® and Fujirebio Lumipulse ® , evaluated Simoa-referenced harmonization, validated Elecsys ® clinical associations, and …

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Real-world analytical and clinical evaluation of the Siemens Atellica® immunoassay for plasma neurofilament light chain in multiple sclerosis

Valerio Nicolella, Carmela Polito, Vincenzo Criscuolo, Rosa Sirica et autres

BACKGROUND: Plasma neurofilament light chain (pNfL) is an established biomarker of neuroaxonal injury in multiple sclerosis (MS), but analytical variability across platforms may limit clinical comparability. OBJECTIVE: We compared pNfL values obtained using Lumipulse® and Atellica® assays, and evaluated the clinical correlates …

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Sex hormone balance and PSA-derived biomarkers in cancer-free African migrant men in Italy: Implications for prostate cancer early detection

Felice Crocetto, Matteo Ferro, Gianluigi Carbone, Mariano Fiorenza et autres

Background: Men of African ancestry experience a disproportionate burden of prostate cancer (PCa), with higher incidence and mortality than men of European ancestry. Although social determinants of health, barriers to care, and delayed diagnosis are key contributors to these disparities, ancestry- and …

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Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli et autres

Abstract Thyroid hormone (TH) is a critical regulator of skeletal muscle (SkM) physiology, influencing muscle development, metabolism and contractile function. However, the molecular mechanisms by which TH modulates muscle excitability and contraction remain incompletely defined. Here, we investigated the role of TH …

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Elevated plasma sTREM2 reflects microglial activation but lacks diagnostic and clinical relevance in amyotrophic lateral sclerosis

Gianmaria Senerchia, Valentina Virginia Iuzzolino, Myriam Spisto, Fabiana Panico et autres

Microglial activation contributes to the neuroinflammatory response in amyotrophic lateral sclerosis (ALS). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) reflects microglial activity in several neurodegenerative disorders, but its role in ALS remains unclear. We evaluated plasma sTREM2 as a marker …

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Plasma NfL, GFAP and pTau181 define distinct biological axes in amyotrophic lateral sclerosis

Gianmaria Senerchia, Valentina Virginia Iuzzolino, Myriam Spisto, Fabiana Panico et autres

Amyotrophic lateral sclerosis is biologically heterogeneous, and blood biomarkers may reflect distinct pathological mechanisms. We investigated whether plasma neurofilament light chain (NfL), phosphorylated tau at threonine 181 (pTAU181), and glial fibrillary acidic protein (GFAP) capture complementary biological domains in amyotrophic lateral sclerosis. …

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Immunohistochemical and serum profile of squamous cell carcinoma of the vulva: The Dual Vulvar Panel (DVP) project

Luigi Della Corte, Mario Francesco Palumbo, Chiara Mignogna, Silvia Varricchio et autres

INTRODUCTION: This study aimed to evaluate the expression of selected immunohistochemical (IHC) markers and serum squamous cell carcinoma antigen (SCC-Ag) in vulvar squamous cell carcinoma (VSCC), and to investigate associations with recurrence and death using molecular clustering and diagnostic performance analyses. STUDY …

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Cell-free RNA profiling uncovers non-canonical circulating D2 transcript elevation in Bladder Cancer plasma

Annarita Nappi, Felice Crocetto, Paolo Conforti, Serena Sagliocchi et autres

Background: D2 overexpression has emerged as a recurrent molecular feature across multiple cutaneous malignancies, where it contributes to aberrant Thyroid Hormone (TH) activation and tumor-associated metabolic reprogramming. Liquid biopsy approaches based on circulating cell-free RNA (cfRNA) is emerging as non-invasive strategy to …

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Plasma neurofilament light chain to evaluate response during cladribine treatment in multiple sclerosis

Valerio Nicolella, Marco Varelli, Stefania Fasano, Rosa Sirica et autres

INTRODUCTION: Cladribine treatment in year 1 and 2 provides high efficacy on multiple sclerosis(MS) outcomes over 4 years. Use of biomarkers of neuro-axonal damage, such as plasma neurofilament light chain (pNfL), might support prognostication and treatment decisions. OBJECTIVES: To:1)investigate pNfL variations over …

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Investigating the contribution of laboratory parameters on plasma neurofilament light chain levels in multiple sclerosis

Valerio Nicolella, Monica Gelzo, Giuseppina Affinito, Sveva Bagnasco et autres

Objective To investigate the associations between several laboratory parameters and plasma neurofilament light chain (pNfL) in individuals with multiple sclerosis (MS), as well as their additional contribution to the established relationships between pNfL, demographics, and MS disability. Methods In this cross-sectional study, …

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Plasma Neurofilament Light Chain Is Associated with Cognitive Functions but Not Patient-Reported Outcomes in Multiple Sclerosis

Valerio Nicolella, Federica Novarella, Fabrizia Falco, Rosa Sirica et autres

Objective: We aimed to explore associations between plasma neurofilament light chain (pNfL) and cognition through patient-reported outcomes (PROs) in multiple sclerosis (MS). Methods: In this cross-sectional study, we included 211 people with MS (PwMS) and collected data from pNfL (fully automated chemiluminescent …

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