R. Syed

Discovery of benzyl carbamate inhibitors of coronavirus M pro enzymes from a legacy collection of cysteine protease inhibitors

Mateus Sá Magalhães Serafim, Thales Kronenberger, Karol R. Francisco, Erik Vinícius de Sousa Reis et autres

The constant emergence of SARS-CoV-2 resistance drives the search for new antivirals. We screened the SARS-CoV-2 cysteine proteases, the main protease (Mpro) and papain-like protease (PLpro), with 141 peptidyl and peptidomimetic inhibitors designed to target a trypanosome cysteine protease. Five compounds (1a–5a) …

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HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE

Janet C. Cheetham, Duncan M. Smith, Kenneth H. Aoki, Janice L. Stevenson et autres

CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS

R. Syed, C. Li

POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R78206

Robert A. Grant, Chaitanya N. Hiremath, David J. Filman, R. Syed et autres

POLIOVIRUS (TYPE 3, SABIN STRAIN, MUTANT 242-H2) COMPLEXED WITH R78206

Robert A. Grant, Chaitanya N. Hiremath, David J. Filman, R. Syed et autres

POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R77975

Robert A. Grant, Chaitanya N. Hiremath, David J. Filman, R. Syed et autres

REFINEMENT OF THE SABIN STRAIN OF TYPE 3 POLIOVIRUS AT 2.4 ANGSTROMS AND THE CRYSTAL STRUCTURES OF ITS VARIANTS AT 2.9 ANGSTROMS RESOLUTION

R. Syed, David J. Filman, J.M. Hogle

Role and mechanism of the maturation cleavage of VP0 in poliovirus assembly: Structure of the empty capsid assembly intermediate at 2.9 Å resolution

Ravi Basavappa, David J. Filman, R. Syed, Ornella Flore et autres

The crystal structure of the P1/Mahoney poliovirus empty capsid has been determined at 2.9 A resolution. The empty capsids differ from mature virions in that they lack the viral RNA and have yet to undergo a stabilizing maturation cleavage of VP0 to …

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Structures of poliovirus complexes with antiviral drugs: implications for drug design, capsid stability, and viral uncoating

Robert A. Grant, Chaitanya N. Hiremath, David J. Filman, R. Syed et autres

Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus.

David J. Filman, R. Syed, M Chow, Andrew J. Macadam et autres

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Carbonatobis(triethylphosphine)platinum(II)

John A. Davies, Cassandra T. Eagle, A. Alan Pinkerton, R. Syed

Synthesis, X-ray structure and electrochemistry of [Pd3(μ-CO)2(C5Me5)3][CF3SO3]

Neil M. Boag, David S. Boucher, John A. Davies, A. Alan Pinkerton et autres

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