Erik Vinícius de Sousa Reis

SARS-CoV-2 drives upregulation of EpCAM in respiratory epithelial cells with hypercellular profile during severe COVID-19

Franklin Pereira Araújo, Geovane Marques-Ferreira, Camila Pacheco Silveira Martins da Mata, Erik Vinícius de Sousa Reis et autres

BACKGROUND: At the end of 2019, severe acute respiratory syndrome (SARS) caused by the novel coronavirus SARS-CoV-2 emerged in China, representing one of the most significant global health threats of the twenty-first century. This study aimed to evaluate the phenotypic and cellular …

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Immune landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*02+ individuals from Brazil

Ágata Lopes-Ribeiro, Geovane Marques-Ferreira, Franklin Pereira Araújo, Patrícia de Melo Oliveira et autres

Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the major histocompatibility complex-restricted virus-specific responses of acute and postacute COVID-19 patients. Our results indicate that convalescent …

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Cannabidiol promotes fine-tuning of natural killer and monocytic cells subsets as well as cytokine storm during chikungunya virus exposure in vitro: Insights for putative therapeutic interventions

Erik Vinícius de Sousa Reis, Ágata Lopes-Ribeiro, Thaís de Fátima Silva Moraes, Geovane Marques Ferreira et autres

Chikungunya virus (CHIKV) is an arbovirus that causes acute and chronic disease by strong stimulation of the immune system. It activates innate and adaptive immune cells, including monocytes, natural killer (NK) cells, and lymphocytes, as well as soluble mediators such as IL-17A, …

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Discovery of benzyl carbamate inhibitors of coronavirus M pro enzymes from a legacy collection of cysteine protease inhibitors

Mateus Sá Magalhães Serafim, Thales Kronenberger, Karol R. Francisco, Erik Vinícius de Sousa Reis et autres

The constant emergence of SARS-CoV-2 resistance drives the search for new antivirals. We screened the SARS-CoV-2 cysteine proteases, the main protease (Mpro) and papain-like protease (PLpro), with 141 peptidyl and peptidomimetic inhibitors designed to target a trypanosome cysteine protease. Five compounds (1a–5a) …

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New aminoadamantane derivatives as inhibitors of F13 envelope protein from mpox virus

Thaís de Fátima Silva Moraes, Erik Vinícius de Sousa Reis, Gabriela Aparecida Azevedo, Mateus Sá Magalhães Serafim et autres

Mpox is a zoonotic viral disease caused by monkeypox virus (MPV), currently classified as a public health emergency of international concern by the WHO. In this study, Aminoadamantane (AMA) and five synthetic derivatives were evaluated as potential candidates for treating mpox. The …

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Novel Multifunctional Cannabidiol-Based Analogues with In Silico, In Vitro, and In Vivo Anti-SARS-CoV-2 Effect

Graziella dos Reis Rosa Franco, Vanessa Silva Gontijo, Flávia P. Dias Viegas, Matheus de Freitas Silva et autres

Background/Objectives: COVID-19 was responsible for millions of deaths worldwide. This study aimed to identify substances with in vitro and in vivo effects against the SARS-CoV-2 virus. Methods: Compounds PQM-243 and PQM-249, two terpene-N-acyl-aryl-hydrazone analogues, were evaluated in vitro against SARS-CoV-2 to a …

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Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail

Matheus Francisco Barros Rodrigues, Victória Fulgêncio Queiroz, Thalita Souza Arantes, Henrique Limborço et autres

Numerous studies have shown that viruses are present in a variety of environments on Earth, acting as drivers of biogeochemical cycles and powerful selective forces. Among them, giant viruses of amoebae have garnered attention from the scientific community due to their large …

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A pain from the nose to the head: neurological commitment during long COVID

Laura Cardoso Corrêa-Dias, Ágata Lopes-Ribeiro, Geovane Marques-Ferreira, Caio Wilker-Teixeira et autres

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Immunogenicity and safety of CoronaVac vaccine in children and adolescents (Immunita-002, Brazil): A phase IV six-month follow up

Camila Amormino Corsini, Priscila Fernanda da Silva Martins, Priscilla Soares Filgueiras, Adelina Júnia Lourenço et autres

Vaccines are essential for the prevention and control of several diseases, and monitoring the immune response generated by vaccines is crucial. The immune response generated by vaccination against SARS-CoV-2 in children and adolescents is not well defined in terms of the intensity …

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Novel multifunctional Cannabidiol-Based Analogues with In Silico, In Vitro, and In vivo anti-SARS-COV-2 effect

Vanessa Silva Gontijo, Flávia P. Dias Viegas, Matheus Silva, Cindy Juliet Cristancho Ortiz et autres

Background and Purpose: COVID-19 was responsible for millions of deaths worldwide. This study aimed to identify substances with in vitro and in vivo effect agains the virus. Experimental Approach: compounds PQM-243 and PQM-249, two terpene-N-acyl-aryl-hydrazone analogues were evaluated in vitro against SARS-CoV-2 …

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Correction to: HCV immunodominant peptide mapping reveals unique HLA‑A* 02‑restricted signatures: insights for CD8+ T‑cell‑based vaccines and immunotherapies

Laura Cardoso Corrêa-Dias, Ágata Lopes-Ribeiro, Geovane Marques-Ferreira, Letícia Gomes de Pontes et autres

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Antiviral effect of Bromelain combined with acetylcysteine against SARS-CoV-2 Omicron variant

Erik Vinícius de Sousa Reis, Linziane Lopes Ferreira, Felipe Alves Clarindo, Geovane Marques-Ferreira et autres

The recent pandemic represented one of the biggest challenges of modern civilization. SARS-CoV-2 remains an imminent public health threat and currently, there is no effective and greatly affordable treatment for severe COVID-19. Although standard management with dexamethasone, and physical management including physiotherapy, …

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