Accès ouvert
2026
article
OpenAlex
Yuan-Hao Wu, Chen Guo, Zi-Ru Ye, Xi-Le Hu et autres
Ever-increasing evidence confirms the role of O-GlcNAcase (OGA) in mediating cell growth and development as well as pathology and underscores the importance of developing sensitive and selective chemical tools for the study of OGA biology. Here, based on our previously developed protein-encapsulation …
cn, gb
(code pays fourni par la source)
2025
article
OpenAlex
Jingjie Yang, Xueru Zhao, Chen-Han Wang, Xi-Le Hu et autres
Glycosidases generally function in specific organelles to hydrolyze glycoconjugates. Thus, the in situ visualization of glycosidase activities in an organelle-targeted manner can help to better delineate their biological functions. Lysosomal β-galactosidase (β-Gal) is reported to be a biomarker for ovarian cancer and …
cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hui Fang Xu, Danyang Chen, Xi-Le Hu, Guo‐Rong Chen et autres
The exploitation of glycans as targeting agents to construct delivery materials has proved useful for targeted disease diagnosis and therapy. To achieve effective targeting, multivalent glycosides are prepared to enhance avidity with sugar receptors. In this study, we designed and synthesized a …
cn, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Chen Guo, Fang-Yu Si, Chen-Han Wang, Ning Wang et autres
Multivalent glycoclusters have been extensively used as a targeting agent for drug delivery. However, tools capable of investigating their dynamic interactions with a target receptor remain elusive. Here, we synthesized fluorescently-tagged galactoclusters for the fluorescence imaging of cells that overly express the …
cn, gb
(code pays fourni par la source)
2025
article
OpenAlex
Hai‐Hao Han, Xi-Le Hu, Xiao‐Peng He
Fluorescent glycoconjugate probes have emerged as innovative tools for biomedical research, helping to delineate the mechanistic roles of sugars in biological and pathological events. This feature article reviews the recent advances in the development and application of fluorescent glycoconjugate probes since 2021, …
cn
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Linyang Chu, Ying Yang, Shengbing Yang, Qiming Fan et autres
Implant-related infection is a devastating complication in clinical trauma and orthopedics. The aim of this study is to use a bifunctional biomaterial surface in order to investigate the competitive colonization between osteoblasts and bacteria, which is the cause of implant-related infection. A …
cn, jp, gb
(code pays fourni par la source)