Linyang Chu

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Tianyou Kan, Xuran Li, H Y Wang, Lin Sun et autres

ABSTRACT Mechanical stress is the most important factor affecting the progression of osteoarthritis (OA), but the mechanism linking mechanical stress to transcriptional repression remains elusive. Here, the study finds that mechanical stress induced epigenetic changes that can serve as therapeutic targets for …

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Piezo1 transduces mechanical signals to inhibit osteoclast fusion and coordinate bone homeostasis

Ying Wang, H Y Wang, Tianyou Kan, Junqi Cui et autres

ABSTRACT Osteoclasts originate from bone marrow–derived macrophages, and their maturation relies on fusion of pre-osteoclasts into mature osteoclasts that maintain bone homeostasis. Previous studies established that mechanical signals regulate osteoblast activity in bone homeostasis, although whether such signals regulate bone homeostasis by …

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Trio-active bone scaffold with multivalent ion doping establishes an osteo–angio–immune bone regenerative axis

Jiren Yan, Xiang Li, Teng Ye, Weinan Cheng et autres

Effective reconstruction of critical-sized bone defect remains clinically challenging due to suboptimal osteogenic capacity, inadequate vascularization, and inflammatory complications associated with current autologous bone grafts or synthetic substitutes. To address these limitations, we developed a bioactive scaffold composed of hydroxyapatite doped with …

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Articular cartilage degeneration and aberrant osteocyte perilacunar/canalicular remodeling in subchondral bone of patients with developmental dysplasia of the hip

Teng Ye, Jiren Yan, Tianyou Kan, Guoming Xie et autres

BACKGROUND: Developmental dysplasia of the hip (DDH) is a congenital musculoskeletal disease that impairs the hip joint and exacerbates hip osteoarthritis. This study aims to investigate the alterations of osteocytic characteristics including apoptosis, lacuna-canalicular network, and perilacunar/canalicular remodeling (PLR) activity in subchondral …

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Novel Fundus Image Preprocessing for Retcam Images to Improve Deep Learning Classification of Retinopathy of Prematurity

Sajid Rahim, Kourosh Sabri, Anna L. Ells, Alan Wassyng et autres

Retinopathy of Prematurity (ROP) is a potentially blinding eye disorder because of damage to the eye's retina which can affect babies born prematurely. Screening of ROP is essential for early detection and treatment. This is a laborious and manual process which requires …

Early Emergent and Progressive Aberrant Subchondral Bone Remodeling Coupled with Aggravated Cartilage Degeneration in Developmental Dysplasia of the Hip

Teng Ye, Feng Xue, Hai Xia Hu, Zihao He et autres

OBJECTIVE: Developmental dysplasia of the hip (DDH) is the most common skeletal development in children and could result in secondary osteoarthritis. This study aims to clarify the alternations of subchondral trabecular bone remodeling and microstructural properties during the development of DDH, and …

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Abnormal subchondral trabecular bone remodeling in knee osteoarthritis under the influence of knee alignment

Xuequan Han, Junqi Cui, Linyang Chu, Weituo Zhang et autres

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Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study

Feng Zhou, Linyang Chu, Xuqiang Liu, Zihao He et autres

Osteoporotic osteoarthritis (OP-OA) is a specific type of OA. In this study, we aimed to assess the subchondral plate and rod microstructural differences between OA and OP-OA patients by using an individual trabeculae segmentation (ITS) system and to analyze the relationships between …

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Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study

Xuequan Han, Junqi Cui, Kai Fang Xie, Xu Jiang et autres

BACKGROUND: Knee osteoarthritis (OA) is a common disabling disease involving the entire joint tissue, and its onset and progression are affected by many factors. However, the current number of studies investigating the relationship between subchondral trabecular bone (STB), knee alignment, and OA …

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Differences in subchondral trabecular bone microstructure and finite element analysis-based biomechanical properties between osteoporosis and osteoarthritis

Zihao He, Linyang Chu, Xuqiang Liu, Xuequan Han et autres

BACKGROUND/OBJECTIVE: The microstructure of the subchondral trabecular bone, including the composition and distribution of plates and rods, has an important influence on the disease progression and mechanical properties of osteoarthritis (OA) and osteoporosis (OP). We aimed to determine whether differences in plates …

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Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone

Yong Dai, Han Guo, Linyang Chu, Zihao He et autres

To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths. Suspension coating and melt bonding. Silicon nitride (Si3N4, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid …

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Articular Cartilage Degradation and Aberrant Subchondral Bone Remodeling in Patients with Osteoarthritis and Osteoporosis

Linyang Chu, Xuqiang Liu, Zihao He, Xuequan Han et autres

Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP changes on OA progression in patients with osteoporotic OA (OP-OA) has not been reported, especially …

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