Pathological characteristics of coxsackievirus A14 in neonatal mice model
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Le résumé fourni par la source
In recent years, with the increasing incidence of other non-EV-A71 enteroviruses, the research on other enteroviruses has become more and more important. Coxsackievirus A14 (CVA14), A member of the enterovirus group A, causes hand-foot-mouth disease (HFMD), aseptic meningitis and acute abdominal pain. In this study, we established the first ICR mouse model of CVA14 infection. The CVA14 HE27 strain was selected to infect neonatal mice through a preliminary experiment, and the infection model was established according to three different conditions of infection dose, route and age. It was found that 2-day-old ICR neonatal mice showed clinical symptoms such as hind limb paralysis and death after intramuscular injection of 105.75 TCID50 CVA14 HE27 strain. Through daily monitoring, we found that the viral load of skeletal muscle was the highest, and there were certain pathological changes in various tissues and organs, among which the changes of brain and skeletal muscle were the most obvious. The expression of pro-inflammatory cytokines IL-4, IL-10, IFN-γ and TNF-α were abnormally high. This neonatal mouse model of CVA14 infection will be useful for the development of prophylactic and therapeutic multivalent vaccines, as well as for the screening of antiviral drugs against enterovirus.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pathological characteristics of coxsackievirus A14 in neonatal mice model
- Date Crossref
- 14/01/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Health and Family Planning Commission pays non établi dans la noticeOrganisme public
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National Institute for Viral Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Shandong First Medical University pays non établi dans la noticeUniversité ou école supérieure
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Weifang Medical University pays non établi dans la noticeUniversité ou école supérieure
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National Polio Laboratory pays non établi dans la noticeStructure de recherche
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School of Basic Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention et Shandong First Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.