EBERHARD G. SIEGEL

Effect of human pancreastatin peptide (hP-16) on oral glucose tolerance in man

EBERHARD G. SIEGEL, B. Gallwitz, Ulrich R. Fölsch, Wolfgang E. Schmidt

The gastrointestinal peptide, pancreastatin, has been shown to inhibit insulin release and exocrine pancreatic secretion in the rat. Human pancreastatin-like peptides first isolated from a carcinoid tumor, are expressed in human islets of Langerhans. To investigate the influence of human pancreastatin-16 (hP-16) …

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Repeated Upper Gastrointestinal Hemorrhage Caused by Metachromatic Leukodystrophy of the Gall Bladder

EBERHARD G. SIEGEL, Heinrich Lücke, Walter Schauer, W Creutzfeldt

A 27-year-old man with metachromatic leukodystrophy (MLD) of the adult type had developed repeated severe gastrointestinal (GI) bleeding. During endoscopic retrograde cholangiography (ERC), hemobilia was observed on two occasions. The definite diagnosis was obtained by a biopsy specimen taken from the lumen …

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Effect of a Specific Serine Protease Inhibitor on the Rat Pancreas

Burkhard Göke, EBERHARD G. SIEGEL, Fritz Stöckmann, P. G. Lankisch et autres

Chronic oral administration of camostate, a specific serine protease inhibitor, is known to induce pancreas hypertrophy in rats. A possible influence of the protease inhibitor on the endocrine rat pancreas was studied using isolated perfused pancreas and islet incubations. The presence of …

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Announcement

M. Staritz, Klaus Ewe, Karl H. Meyer zum Büschenfelde, Takeo Yoshikawa et autres

This symposium, under the chairmanship of Prof. S/urs/cwski.will cover basic and clinical research on neural, humoral, and myogenic mechanisms of con trol of gastrointestinal motility in health and disease.The purpose of this meeting is to bring together inves tigators and clinical scientists …

Author Index

M. Staritz, Klaus Ewe, Karl H. Meyer zum Büschenfelde, Takaki Yoshikawa et autres

Inhibition of Glycemic and Hormonal Responses after Repetitive Sucrose and Starch Loads by Different Doses of the α-Glucosidase Inhibitor Miglitol (BAY m 1099) in Man

Bernhard Lembcke, U.R. F ouml lsch, Wolfgang Gatzemeier, Reinhold Ebert et autres

In two randomized, placebo-controlled, double-blind studies, the efficacy, duration of action and tolerability of a single morning dose of 25, 50, and 100 mg miglitol (BAY m 1099), an absorbable inhibitor of intestinal alpha-glucosidases, were assessed after repetitive sucrose or maize-starch loads …

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Kompressionstherapie nach tiefer Beinvenenthrombose

EBERHARD G. SIEGEL, Alex Bastian

Frage: Die lege artis durchgeführte Kompressionstherapie gilt als unverzichtbare Säule der Therapie tiefer Beinvenenthrombosen. Wie ist jedoch zu verfahren, wenn ein postthrombotisches Syndrom mit farbduplexsonographisch und phlebographisch nachgewiesenen fast vollständigen Verschlüssen der tiefen Leitvenen bis in die Beckenetage vorliegt? Der venöse Abfluss …

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Wearable microdialysis system for continuous in vivo monitoring of glucose

Thomas Vering, S. Adam, H. Drewer, C. Dumschat et autres

We developed a new system to monitor glucose continuously in vivo. The miniaturised system is very easy to handle and was optimised to a resource-saving working modus. Sampling was performed by means of a biocompatible microdialysis needle probe inserted into the subcutaneous …

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Hydroxyethyl starch does not improve pancreas preservation with HTK

Alex Tytko, Beate G. Exner, Evelin Schröck, Mandy Barthel et autres

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Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation

Michael Albrecht Nauck, M. B�sing, C. �rskov, EBERHARD G. SIEGEL et autres

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Critical evaluation of the ‘heated‐hand‐technique’ for obtaining ‘arterialized’ venous blood: incomplete arterialization and alterations in glucagon responses

Michael Albrecht Nauck, Hans Dieter Liess, EBERHARD G. SIEGEL, Paul Dieter Niedmann et autres

In order to test the degree of 'arterialization' and the occurrence of arterio- (or capillary-) venous differences in glucose concentrations for commonly used blood sampling sites (including the retrogradely cannulated dorsal hand vein with application of dry heat to this hand/arm--the 'heated-hand-technique'), …

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Comparison of the effect of GIP and GLP‐1 (7–36amide) on insulin release from rat pancreatic islets

EBERHARD G. SIEGEL, Antina Schulze, Wolfgang Ekkehard Schmidt, W. Creutzfeldt

After ingestion of glucose both GIP (gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide) and GLP-1(7-36amide) (glucagon-like polypeptide-1, 7-36amide) may play a physiological role in augmenting insulin release. Their insulinotropic effect was compared in isolated rat islets after 24-h maintenance in tissue culture (11 …

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