Ulrich R. Fölsch

English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis

Albrecht Hoffmeister, Julia V. Mayerle, Christoph Beglinger, M.W. Büchler et autres

Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes result in replacement of pancreatic parenchyma by fibrous connective tissue. This fibrotic reorganization of the pancreas leads to a progressive exocrine and endocrine pancreatic insufficiency. In addition, characteristic complications …

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Arzneimitteltherapiesicherheit und Innere Medizin

Daniel Grandt, Ulrich R. Fölsch

Therapieschemata werden wirksamer, aber auch komplexer. Immer ältere und immer multimorbidere Patienten erhalten neben bekannten auch zahlreiche neue Arzneimittel. Nicht selten werden diese Patienten von fünf oder sogar mehr Ärzten betreut. Eine Untersuchung bei multimorbiden Patienten in 11 Ländern ergab, dass die …

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S3 Guidelines for Colorectal Carcinoma

Wolff Schmiegel, Christian Peter Pox, A. C. Reinacher-Schick, G. Adler et autres

Representing the German Society for Digestive-and Metabolic Diseases (DGVS) and the German Cancer Society (DKG) In collaboration with the: German Society for Visceral Surgery (DGVC) German Society for Haematology and Oncology (DGHO) German Society of Pathology (DGP) German Society of Radio-oncology (DEGRO) …

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Effect of human pancreastatin peptide (hP-16) on oral glucose tolerance in man

EBERHARD G. SIEGEL, B. Gallwitz, Ulrich R. Fölsch, Wolfgang E. Schmidt

The gastrointestinal peptide, pancreastatin, has been shown to inhibit insulin release and exocrine pancreatic secretion in the rat. Human pancreastatin-like peptides first isolated from a carcinoid tumor, are expressed in human islets of Langerhans. To investigate the influence of human pancreastatin-16 (hP-16) …

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Weekly High-Dose 5-Fluorouracil 24-Hour Infusion and Intermediate-Dose Folinic Acid Bolus in Metastatic Colorectal Cancer

C. Stoffregen, K.‐H. Zurborn, Volkmar Boehme, Andreas Schmid et autres

Background: Weekly high-dose 5-fluorouracil (5-FU; 24-hour infusion of 2.6 g/m2) and folinic acid (FA; 500 mg/m2as 1- or 2-hour infusion) proved to be effective in patients with metastatic colorectal cancer. The minimum effective dosages of the drugs required in this schedule, however, …

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900 CAVEOLIN-2 Q130E GENE POLYMORPHISM IS HIGHLY ASSOCIATED WITH RESPONSE TO ANTIVIRAL THERAPY IN HEPATITIS C AND CLINICAL FEATURES OF HEPATIC STEATOSIS

Deborah M Rubin, H. Vollbrecht, Susanne Ross, Selim M Nasser et autres

Effect of Short- and Long-Term Feeding of Omeprazole on Rat Gastric Endocrine Cells

W. Creutzfeldt, Fritz Stöckmann, J. Michael Conlon, Ulrich R. Fölsch et autres

Rats were tube-fed with omeprazole (40 mumol/kg body weight twice daily) for 30 and 60 days. As a result, fasting plasma gastrin levels were significantly elevated, while plasma somatostatin levels remained normal. Gastrin concentrations in the antral mucosa were unchanged after 30 …

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Importance of Intracellular S-Adenosylmethionine Decarboxylase Activity for the Regulation of Camostate-lnduced Pancreatic Polyamine Metabolism and Growth: In vivo Effect of Two Novel S-Adenosylmethionine Decarboxylase Inhibitors

Christian Löser, T. Fitting, Ulrich R. Fölsch

The present study was designed to investigate the inhibitory potency of the two novel S-adenosylmethionine decarboxylase (SAM-DC) inhibitors MDL 73811 and CGP 48664 on the camostate-induced pancreatic polyamine metabolism and especially intracellular spermidine accumulation as well as pancreatic growth in vivo. Male …

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Importance of Various Intracellular Regulatory Mechanisms of Polyamine Metabolism in Camostate-lnduced Pancreatic Growth in Rats

Chr. Löser, Ulrich R. Fölsch

Aim of the present study was to evaluate the relevance of various intracellular regulatory mechanisms of polyamine metabolism in normal and camostate (FOY 305)-induced pancreatic growth in rats. Furthermore it was investigated whether the simultaneous inhibition of the polyamine interconversion pathway by …

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Putrescine Uptake and Metabolism in Isolated Rat Pancreatic Acini

Frauke Alves, E. Stüber, Michael Höcker, Ulrich R. Fölsch

In addition to de novo synthesis, polyamine uptake is one of the major mechanisms in the regulation of intracellular polyamine concentrations. The aim of the present study was to investigate the uptake of putrescine (PUT) in isolated rat pancreatic acini and its …

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Polyamines in Pancreatic Growth

Ulrich R. Fölsch, Christian Löser, F. Alves

This chapter reviews available data concerning the role of polyamines in pancreatic growth. Like in many other mammalian cells stimulation of pancreatic proliferation by trophic factors is associated with an early increase in ornithine decarboxylase (ODC) activity with consequent putrescine formation. ODC …

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Acute and Chronic Effects of Cyclosporine A on Pancreatic Polyamine Metabolism and Pancreatic Adaptation

Christian Löser, Frauke Alves, Fritz Stöckmann, Ulrich R. Fölsch et autres

The present study was designed to investigate the effects of acute and chronic application of the immunosuppressive agent cyclosporine A (CsA) on pancreatic polyamine metabolism as well as pancreatic growth of rats in vivo. Seven to ten animals per group were treated …

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