Yuan‐Soon Ho

Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

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Nicotine‐driven enhancement of tumor malignancy in triple‐negative breast cancer via additive regulation of CHRNA9 and IGF1R

Yung‐Che Kuo, Chi‐Long Chen, Kha‐Liang Lee, Hsiao‐Feng Wang et autres

Cigarette smoking is a significant risk factor for cancer development with complex mechanisms. This study aims to investigate the impact of nicotine exposure on the regulation of stemness- and metastasis-related properties via cholinergic receptor nicotinic alpha 9 subunit (CHRNA9) and insulin-like growth …

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A deep dive into the orchard of health: Exploring the anti-cancer and anti-aging potential of apple polyphenols

Li-Ching Chen, Han‐Sheng Chang, Yuan‐Soon Ho

Apples, a ubiquitous and beloved fruit, harbor a treasure trove of bioactive compounds, with apple polyphenols (APs) taking center stage. This review delves into the latest scientific advancements illuminating the anti-cancer and anti-aging properties of APs. We dissect the intricate mechanisms by …

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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu‐Chun Cheng, Mien‐Chie Hung, Lu-Hai Wang, Shih‐Hsin Tu et autres

BACKGROUND: Up to 23% of breast cancer patients recurred within a decade after trastuzumab treatment. Conversely, one trial found that patients with low HER2 expression and metastatic breast cancer had a positive response to trastuzumab-deruxtecan (T-Dxd). This indicates that relying solely on …

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RNA Nanotechnology for Codelivering High-Payload Nucleoside Analogs to Cancer with a Synergetic Effect

Xin Li, Kai Jin, You-Cheng Liao, Wen-Jui Lee et autres

Nucleoside analogs are potent inhibitors for cancer treatment, but the main obstacles to their application in humans are their toxicity, nonspecificity, and lack of targeted delivery tools. Here, we report the use of RNA four-way junctions (4WJs) to deliver two nucleoside analogs, …

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Investigation of the α9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer

You-Cheng Liao, Lu‐Hai Wang, Mien‐Chie Hung, Tzu‐Chun Cheng et autres

α9-nAChR, a subtype of nicotinic acetylcholine receptor, is significantly overexpressed in female breast cancer tumor tissues compared to normal tissues. Previous studies have proposed that specific single nucleotide polymorphisms (SNPs) in the CHRNA9 (α9-nAChR) gene are associated with an increased risk of …

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P13-15 Investigation of the α9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer

Yuan‐Soon Ho, Yu-Cheng Liao, L.-C. Chen

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Apple polyphenol phloretin inhibits type Ⅱ glucose transporter and enhances anti-HER2 antibody drug binding as an adjuvant treatment for HER2-positive breast cancer

Han‐Sheng Chang, Tzu‐Chun Cheng, Shih‐Hsin Tu, Pei-Han Liao et autres

This study presents novel findings on the potential of phloretin, an apple polyphenol, to enhance the effectiveness of anti-HER2 antibody therapy in HER2-positive breast cancer patients. Our research reveals that phloretin inhibits type II glucose transporter (GLUT2) activity, significantly reducing cancer cell …

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Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer

Han‐Sheng Chang, Tzu‐Chun Cheng, Shih‐Hsin Tu, Chih‐Hsiung Wu et autres

Trastuzumab resistance is one of the causes of poor prognosis in patients with HER2-positive (HER2+) breast cancer (BC). The truncated isoform of dopamine- and cAMP-regulated phosphoprotein (t-DARPP) has been reported to be involved in Trastuzumab therapy resistance and promoting tumor progression. To …

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StAR-related lipid transfer domain protein 3 (STARD3) regulates HER2 and promotes HER2-positive breast cancer progression through interaction with HSP90 and SRC signaling.

Doan Huu Nhat Binh, Tzu‐Chun Cheng, Shih‐Hsin Tu, You-Cheng Liao et autres

Although various HER2-targeted therapies have been approved clinically, drug resistance remains a considerable challenge. Studies have found that the cause of drug resistance is related to the expression of genes co-amplified with HER2 in breast cancer cells. Our study found that STARD3 …

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The extended concurrent genes signature for disease-free survival in breast cancer

Ching-Shui Huang, Ming‐Lin Tsai, Tzu‐Pin Lu, Chao‐Chiang Tu et autres

BACKGROUND/PURPOSE: Previously we had identified concurrent genes, which highlighted the interplay between copy number variation (CNV) and differential gene expression (GE) for Han Chinese breast cancers. The merit of the approach is to discovery biomarkers not identifiable by conventional GE only data, …

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Curcumin-induced antitumor effects on triple-negative breast cancer patient-derived xenograft tumor mice through inhibiting salt-induced kinase-3 protein

Tzu‐Chun Cheng, John Oliver Sayseng, Shih‐Hsin Tu, Ting-Ching Juan et autres

This study demonstrated for the first time that curcumin effectively inhibits the growth of triple-negative breast cancer (TNBC) tumors by inhibiting the expression of salt-induced kinase-3 (SIK3) protein in patient-derived xenografted tumor mice (TNBC-PDX). For TNBC patients, chemotherapy is the only option …

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