Weonbin Im

Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents

Jonas Engler, Eun‐Jung Kim, Dasol Kim, Noreene M. Shibata et autres

In Wilson disease (WD), excess copper provokes hepatocyte death due to impaired copper excretion, ultimately causing either acute or chronic liver damage. Current therapeutic compounds fail to reduce hepatic copper near to physiological levels, leaving lifelong, several times daily treatment as the …

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ARBM-101 as an emerging potent therapeutic option for Wilson disease

Banu Akdogan, Eun‐Jung Kim, Emilie Munk, Dasol Kim et autres

ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats

Claudia Einer, Ditte Emilie Munk, Eok Park, Banu Akdogan et autres

BACKGROUND & AIMS: Excess copper causes hepatocyte death in hereditary Wilson's disease (WD). Current WD treatments by copper-binding chelators may gradually reduce copper overload; they fail, however, to bring hepatic copper close to normal physiological levels. Consequently, lifelong daily dose regimens are …

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Pharmacological characterization of DA-8010, a novel muscarinic receptor antagonist selective for urinary bladder over salivary gland

Min Jung Lee, Jun-Hwan Moon, Hyung Keun Lee, Chong Hwan Cho et autres

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MP30-15 PHARMACOLOGICAL PROFILE OF DA-8010, A NOVEL BLADDER SELECTIVE MUSCARINIC RECEPTOR 3 ANTAGONIST FOR TREATMENT OF OVERACTIVE BLADDER

Min Jung Lee, Jun-Hwan Moon, Hyun-Min Park, Hyung Keun Lee et autres

respectively (p¼0.05).A significant contractile response of HDSM to PDBu was associated with increased tone in response to muscarinic stimulation but low incidence of spontaneous contractions.CONCLUSIONS: The results of our study provide evidence that the ratio between the peak contractile responses of HDSM …

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Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent

Jung Sang Park, Weonbin Im, Sunghak Choi, Sook Jin Park et autres

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Sa1389 The Safety, Tolerability, and Pharmacokinetics of DA-6886, a Novel Serotonin 5-Hydroxytryptamine4 Receptor Agonist, in Healthy Subjects

Tae‐Young Oh, Mun Ju Choi, Byoung Ok Ahn, Sunghak Choi et autres

Sa2037 Effect of DA-6886 on Gastrointestinal Transit and Defecation in Mice

Kang Hun Cho, Min Jung Lee, Hyun Min Park, Weonbin Im et autres

Sa2025 Effects of DA-6886 on Colonic Motility in Conscious Guinea Pigs

Jun Hwan Moon, Min Jung Lee, Kang Hun Cho, Weonbin Im et autres

Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice

Min Jung Lee, Kang Hun Cho, Hyun Min Park, Hyun Jung Sung et autres

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Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-Resistant and Penicillin-Sensitive Streptococcus pneumoniae

Sunghak Choi, Weonbin Im, Ken F. Bartizal

The in vitro activity of tedizolid (previously known as torezolid, TR-700) against penicillin-resistant Streptococcus pneumoniae (PRSP) clinical isolates and the in vivo efficacy of tedizolid phosphate (torezolid phosphate, TR-701) in murine models of PRSP systemic infection and penicillin-susceptible S. pneumoniae (PSSP) pneumonia …

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DA-6886 is a Novel 5-HT4 Receptor Agonist With Increased Colonic Motor Activity in Mice

Min Jung Lee, Sunghak Choi, Kang Hun Cho, Hyun Min Park et autres