Eugene Moretti

Preoperative Moderate–Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients

Miriam Treggiari, INTUIT Study Investigators, Eugene Moretti, Melissa Adams et autres

BACKGROUND: Excessive daytime sleepiness may reflect increased vulnerability to postoperative neurocognitive disorders given its association with neurodegenerative disease, cognitive decline, and dementia. However, the role of excessive daytime sleepiness in postoperative neurocognitive disorders is unknown. Here, we investigated whether preoperative moderate-severe excessive …

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Preoperative Moderate–Severe Excessive Daytime Sleepiness Is Associated With Postoperative Cognitive Dysfunction in Older Surgical Patients

Michael J. Devinney, Jeffry Takla, Keith W. VanDusen, Mary C. Wright et autres

BACKGROUND: Excessive daytime sleepiness may reflect increased vulnerability to postoperative neurocognitive disorders given its association with neurodegenerative disease, cognitive decline, and dementia. However, the role of excessive daytime sleepiness in postoperative neurocognitive disorders is unknown. Here, we investigated whether preoperative moderate-severe excessive …

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Relationships of Preoperative and 24-Hour Postoperative Plasma and Cerebrospinal Fluid Cytokines with Postoperative Delirium

Michael J. Devinney, Jamarc R Simon, Mary Cooter Wright, Shivam Chand et autres

Abstract Background Postoperative delirium is a common syndrome of acute changes in attention, cognition, and consciousness that may result from inflammation and/or neuroinflammation, but few studies have distinguished the relationships of preoperative and 24-hour postoperative systemic inflammation (i.e. in blood) versus neuroinflammation …

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The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Cohort Study

Andrew R. Spector, Heather Elizabeth Whitson, Mary C. Wright, Jake P. Thomas et autres

BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of postoperative neurocognitive disorder. METHODS: In this …

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Cognitive and Cerebrospinal Fluid Alzheimer’s Disease–related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls

Melody A. Reese, Megan K. Wong, V Wang Cm Seah Wl Chow Sh Lim Ck Cheong, Christine I. Ha et autres

BACKGROUND: Anesthesia and/or surgery accelerate Alzheimer's disease pathology and cause memory deficits in animal models, yet there is a lack of prospective data comparing cerebrospinal fluid (CSF) Alzheimer's disease-related biomarker and cognitive trajectories in older adults who underwent surgery versus those who …

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Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity

Leah Acker, Megan K. Wong, Melody A. Reese, Charlie Giattino et autres

BACKGROUND: In the eyes-closed, awake condition, EEG oscillatory power in the alpha band (7-13 Hz) dominates human spectral activity. With eyes open, however, EEG alpha power substantially decreases. Less alpha attenuation with eyes opening has been associated with inattention; thus, we analysed …

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Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults

Niccolò Terrando, John Park, Michael J. Devinney, Cliburn Chan et autres

Arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) derived lipids play key roles in initiating and resolving inflammation. Neuro-inflammation is thought to play a causal role in perioperative neurocognitive disorders, yet the role of these lipids in the human central …

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Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults

Deborah M. Oyeyemi, Mary L. Cooter, Stacey Chung, Heather Elizabeth Whitson et autres

OBJECTIVE: To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. METHODS: All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores …

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Age-Related Differences in Biomarkers of Acute Inflammation During Hospitalization for Sepsis

Emanuel P. Rivers, Nathan Ivan Shapiro, Eugene Moretti, David Foster Gaieski et autres

To evaluate age-related differences in inflammation biomarkers during the first 72 hours of hospitalization for sepsis.

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults

Chloe K. Nobuhara, William Michael Bullock, Thomas Bunning, Brian J. Colin et autres

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The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction

Miles Berger, Deborah M. Oyeyemi, Mobolaji O Olurinde, Heather Elizabeth Whitson et autres

BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of life, increased mortality, and a possible increased …

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Approaching the Design of an Information Display to Support Critical Care

Kensaku Kawamoto, Guilherme Del Fiol, Charlene R. Weir, Joseph E. Tonna et autres

Well into the electronic health record (EHR) era, interface design issues remain unresolved. When developing EHR displays, human-centered design techniques are often ignored; this results in a cognitive burden on users. Critical care is demanding. Clinicians' cognitive resources (e.g., short-term memory) should …

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