Thomas Bunning

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

Henrik Zetterberg, Michael J. Devinney, Melody R. Smith, Thomas Bunning et autres

Importance: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling to reduce postoperative neuroinflammation and …

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Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

Noah J. Timko, Mary Cooter Wright, Melody R. Smith, Piper C. Boykin et autres

Importance: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling to reduce postoperative neuroinflammation and …

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The Safety, Feasibility and Effect of the APOE Mimetic Peptide CN‐105 on Neuroinflammation and Delirium after Major Non‐cardiac/Non‐neurologic Surgery in Older Adults: Results from the Phase II, Triple Blind, Escalating Dose, MARBLE Randomized Clinical Trial

Miles Berger, Noah J. Timko, Piper C. Boykin, Jacqueline M. Emerson et autres

Abstract Background APOE4 leads to increased neuroinflammation, neurocognitive decline, increased risk of Alzheimer’s disease, and may be associated with increased delirium risk. However, the safety and feasibility of pharmacologic modulation of APOE to prevent neuroinflammation and postoperative delirium is unclear. Methods We …

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A Processed EEG based Brain Anesthetic Resistance Index Predicts Postoperative Delirium in Older Adults: A Dual Center Study

Mary L. Cooter, Thomas Bunning, Sarada Eleswarpu, Mitchell Tod Heflin et autres

ABSTRACT Background Some older adults show exaggerated responses to drugs that act on the brain, such as increased delirium risk in response to anticholinergic drugs. The brain’s response to anesthetic drugs is often measured clinically by processed electroencephalogram (EEG) indices. Thus, we …

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Identifying Patient Phenotype Cohorts Using Prehospital Electronic Health Record Data

Rachel Stemerman, Thomas Bunning, Joseph Grover, Rebecca Rutherford Kitzmiller et autres

Objective: Emergency medical services (EMS) provide critical interventions for patients with acute illness and injury and are important in implementing prehospital emergency care research. Retrospective, manual patient record review, the current reference-standard for identifying patient cohorts, requires significant time and financial investment. …

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The Duke Hotspotting Initiative: Providing Meaningful Clinical Experiences and Improving Clinical Readiness for First-Year Medical Students

Thomas Bunning, Matthew L. Goodwin, Emily Z. Barney, Aarti Thakkar et autres

PROBLEM: Many medical schools now incorporate meaningful clinical experiences for first-year medical students (MS1s). However, these clinical placements often fail to teach components of the physician experience, including health care logistics, cost-conscious care, longitudinal patient care, and interaction with an interprofessional team. …

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A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults

Chloe K. Nobuhara, William Michael Bullock, Thomas Bunning, Brian J. Colin et autres

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3111 Heart Rate Variability as a Predictor of Post-Operative Cognitive Dysfunction in Older Adults

Deborah M. Oyeyemi, Miles Berger, Kenneth Roberts, Charles M. Giattino et autres

OBJECTIVES/SPECIFIC AIMS: The objective of this project is to determine whether HRV, collected peri-operatively, is predictive of cognitive decline among older adults who undergo elective surgery/anesthesia. METHODS/STUDY POPULATION: This project is a part of the ongoing INTUIT/PRIME study, which is collecting pre- …

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The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction

Miles Berger, Deborah M. Oyeyemi, Mobolaji O Olurinde, Heather Elizabeth Whitson et autres

BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of life, increased mortality, and a possible increased …

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