Leah Acker

Clinical Predictors of Resilience following Total Knee Arthroplasty: the PRIME-KNEE Study

V B Kraus, Katherine S. Morris Hall, Cathleen S Colon-Emeric, Heather Elizabeth Whitson et autres

BACKGROUND: We aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasible measures predicting recovery. METHODS: Prospective cohort study …

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Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

Noah J. Timko, Mary Cooter Wright, Melody R. Smith, Piper C. Boykin et autres

Importance: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling to reduce postoperative neuroinflammation and …

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Clinical predictors of resilience following total knee arthroplasty: the PRIME-KNEE study

Cathleen Colón-Emeric, Sarah Peskoe, Marissa C. Ashner, Virginia B. Kraus et autres

BACKGROUND: We aimed to describe recovery trajectories over 6 months in pain intensity, pain interference, lower extremity disability, and physical activity in older adults undergoing elective total knee arthroplasty (TKA), and to identify clinically feasible measures predicting recovery. METHODS: Prospective cohort study …

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Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram

Matthew Stephen Ning, Andrei Rodionov, Jessica Marie Ross, Recep A. Ozdemir et autres

BACKGROUND: Postoperative delirium is the most common complication following surgery amongst older adults, and has been consistently associated with increased mortality and morbidity, cognitive decline, loss of independence and increased health-care costs. We sought to identify preoperative predictors that could identify individuals …

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Neurocognitive Dynamics Underlying Penalty-induced Boosting of Proactive Metacontrol and Its Influence on Reactive Metacontrol

Moon Sun Kang, Leah Acker, Marty G. Woldorff, Yu‐Chin Chiu

Metacontrol states involve adapting cognitive control to contextual demands-being more flexible in frequent task-switching environments or more stable in those with infrequent switching. While these metacontrol states can be engaged proactively in anticipation or reactively in response to specific contexts, how these …

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Aging Brain–Heart–Immune Axis and Postoperative Delirium: A Prospective Observational Study of Preoperative Heart Rate Variability Using At-home Wearable Devices

Kenneth Roberts, Sloan A. Soyster Heinz, Sarah B. Peskoe, Nathaniel Brooke et autres

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Mixed-methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults

Isabella Kjaerulff, Sloan A. Soyster Heinz, Matthew A. Fuller, Mary L. Cooter et autres

BACKGROUND: The effect of psychological distress on general geriatric surgery outcomes remains unexplored despite recommendations for routine, preoperative distress screening. This study aimed to assess preoperative distress measures in a general geriatric surgery cohort and evaluate associations with postoperative outcomes, including delirium, …

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Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies

Melody A. Reese, Mary L. Cooter, Kenneth Roberts, Jeffrey N. Browndyke et autres

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The brain–heart-immune axis: a vago-centric framework for predicting and enhancing resilient recovery in older surgery patients

Leah Acker, Kevin Xu, Jay P. Ginsberg

Nearly all geriatric surgical complications are studied in the context of a single organ system, e.g., cardiac complications and the heart; delirium and the brain; infections and the immune system. Yet, we know that advanced age, physiological stress, and infection all increase …

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Prediction of Postoperative Delirium in Older Adults from Preoperative Cognition and Occipital Alpha Power from Resting-State Electroencephalogram

Matthew Stephen Ning, Andrei Rodionov, Jessica Marie Ross, Recep A. Ozdemir et autres

Background: Postoperative delirium is the most common complication following surgery among older adults, and has been consistently associated with increased mortality and morbidity, cognitive decline, and loss of independence, as well as markedly increased health-care costs. Electroencephalography (EEG) spectral slowing has frequently …

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Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity

Leah Acker, Megan K. Wong, Melody A. Reese, Charlie Giattino et autres

BACKGROUND: In the eyes-closed, awake condition, EEG oscillatory power in the alpha band (7-13 Hz) dominates human spectral activity. With eyes open, however, EEG alpha power substantially decreases. Less alpha attenuation with eyes opening has been associated with inattention; thus, we analysed …

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EEG pre-burst suppression: characterization and inverse association with preoperative cognitive function in older adults

Melody A. Reese, Søren Rahn Christensen, Harel Anolick, Kenneth Roberts et autres

The most common complication in older surgical patients is postoperative delirium (POD). POD is associated with preoperative cognitive impairment and longer durations of intraoperative burst suppression (BSup) – electroencephalography (EEG) with repeated periods of suppression (very low-voltage brain activity). However, BSup has …

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