Shuyan Zhang

The diagnostic and prognostic value of serum FBXO11 expression in neonatal sepsis

Shuyan Zhang, LiLi Ping, SuFang Ma, Ruimin Zhang et autres

This study aimed to investigate the correlation between serum FBXO11 expression and serum PCT and CRP levels as well as its diagnostic and prognostic value in neonatal sepsis (NS). This study included 120 patients with NS aged ≤ 28 days, birth weight …

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Synergistic piezo-immunotherapy enabled by lithium-doped SrTiO3 nanocatalysts for potent tumor ablation through ROS generation and immune activation

Yuzheng Gao, Yichun Zhang, Shuyan Zhang, Zhiwei Yang et autres

Abstract Piezocatalytic tumor therapy represents an emerging approach in cancer treatment, leveraging sonosensitizers to generate reactive oxygen species (ROS) under ultrasound (US) irradiation for effective tumor eradication. However, enhancing ROS production efficiency remains a critical challenge in this field. In this study, …

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Deciphering the therapeutic mechanism of kaempferol in diabetic retinopathy via the P21/Thioredoxin axis

Shuyan Zhang, Leilei Wang, Jiajun Wu, Yinjian Zhang

Diabetic retinopathy (DR) is an irreversible microvascular complication in individuals with diabetes. Kaempferol, a flavonoid with anti-inflammatory, antioxidant, and hypoglycemic activities, has exhibited therapeutic potential in previous investigations for treating DR. However, its accurate molecular mechanisms remain elusive. This study aimed to …

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Immunoregulation mediated by the enzyme inhibitory activity of helminth-derived serine protease inhibitor affects the protective efficiency of vaccines

Wenjie Shi, Yan Liu, Xue Bai, Yue Liang et autres

Recently, the prevalence of trichinellosis has increased the threat to animal food safety and public health worldwide. Pathogen-derived proteins are potential vaccine candidates for preventing and controlling Trichinella spiralis (T. spiralis) infection. However, the effect of protein-induced immunoregulation on vaccine protection remains …

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A Study on the Influencing Factors of Chronic Cough Caused by Mycoplasma Pneumoniae

Miguel Chung Sang, Jiaojiao Wang, Xiaoxiao Jiang, Shuyan Zhang

OBJECTIVE: The purpose of this study was to investigate the risk factors for chronic coughing in children diagnosed with mycoplasma pneumoniae pneumonia (MPP) and provide a reference for a foundation for clinical diagnosis and therapy. METHODS: A retrospective analysis was conducted by …

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Kaempferol Alleviates Dry Eye Disease Via Modulation of the IDH3B/CCAR2/IKBKB Axis

Shuyan Zhang, Yun Xie, Jiaxu Hong

Purpose: Dry eye disease (DED), a multifactorial ocular surface disorder characterized by tear film instability and hyperosmolarity, significantly compromises patients' quality of life. This study evaluates the therapeutic efficacy of kaempferol (KAE), a bioactive flavonoid with demonstrated antioxidant and anti-inflammatory properties and …

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Analysis of Coordination Strategies between Large-Scale Power Users' Direct Participation in Inter-Provincial Spot Markets and Grid-Agent Electricity Procurement

Bo Zhou, Shunfu Lin, Zhiqiang Luo, Shuyan Zhang et autres

This study focuses on analyzing coordination strategies between Large-Scale power users' direct participation in inter-provincial spot markets and Grid-Agent electricity procurement. It aims to provide theoretical support and practical guidance for the stable operation of the electricity market during the reform transition …

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Fabrication of poly(D, L-lactide-co-ε-caprolactone) with elastic-memory function and controlled biodegradability

Lingyu Wei, Qi Chen, Dong Zhou, Lili Gu et autres

Polylactic acid (PLA) is a biodegradable material for tissue engineering, while its mechanical fragility and uncontrollable biodegradability limit its further application in biomedical fields. In this study, a series of poly(D, L-lactide-co-ε-caprolactone) (PDLCL) gradient copolymers were synthesized through ring-opening polymerization by modulating …

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Functionalized Trichinella spiralis anti-tumor protein with polydopamine for hepatocellular carcinoma phototherapy and immunotherapy

Shuyan Zhang, Ning Jiang, Qianqian Dang, Guoliang Chen et autres

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Efficacy of elongated needles for motor and balance function after a stroke: a systematic review and meta-analysis

Shuyan Zhang, Haichun Zhou

Introduction This systematic review aimed to evaluate the efficacy and safety of elongated needle therapy in improving motor and balance functions after stroke, to inform its clinical adoption in rehabilitation. Methods and Analysis We searched PubMed, Web of Science, EMBASE, Medicine, CNKI, …

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A study on the effectiveness and safety of interventional embolization using drug-loaded microspheres in combination with sorafenib and envafolimab for intermediate and advanced renal cell carcinoma

Cheng Chen, Yanfeng Shen, Yanhong Ma, Yingying Zhang et autres

Objective To investigate the effectiveness and safety of drug-loaded microsphere interventional embolization (D-TAE) in conjunction with sorafenib and envafolimab in the management of intermediate and advanced renal carcinoma. Methods 120 cases of intermediate and advanced renal cell carcinoma cured in the Oncology …

Research on the Construction Method of Inter-Provincial Spot Trading Network Model Considering Power Grid Congestion

Hui Cui, Guodong Huang, Jingyang Zhou, Chenxu Hu et autres

This study proposes a full-cost electricity pricing model (M3) based on power flow tracing, addressing limitations in traditional nodal pricing and postage stamp methods. M3 dynamically allocates fixed transmission costs based on actual grid utilization, improving fairness, price signal accuracy, and congestion …

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