Wenjie Shi

The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases

Wenjie Shi, Nuo Xu, Yan Liu, Xue Bai et autres

Allergic diseases are a class of important immune imbalance diseases that lack effective cures. Helminth-derived serine protease inhibitors (serpins) exert immunoregulatory effects similar to those of helminth, are controllable, have few side effects, and have great application potential in correcting unbalanced immune …

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A unique intestinal desensitization strategy: Blocking membrane protease enrichment on macrophages by helminth-derived cystatin-like protein

Wenjie Shi, Yi Liu, Yan Liu, Shui Liu et autres

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Immunoregulation mediated by the enzyme inhibitory activity of helminth-derived serine protease inhibitor affects the protective efficiency of vaccines

Wenjie Shi, Yan Liu, Xue Bai, Yue Liang et autres

Recently, the prevalence of trichinellosis has increased the threat to animal food safety and public health worldwide. Pathogen-derived proteins are potential vaccine candidates for preventing and controlling Trichinella spiralis (T. spiralis) infection. However, the effect of protein-induced immunoregulation on vaccine protection remains …

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The unique activity of the bone morphogenetic protein TGH4 affects the embryonic development of Trichinella spiralis and the establishment of vaccine protection

Wenjie Shi, Yi Liu, Yan Liu, Xue Bai et autres

In recent years, animal outbreaks of trichinellosis have been reported in Mexico, China, Algeria, Croatia and others, which is a challenge to meat safety and public health. Vaccination is an important means to control trichinellosis, but one of the main challenges in …

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Immunosuppressive Ability of Trichinella spiralis Adults Can Ameliorate Type 2 Inflammation in a Murine Allergy Model

Wenjie Shi, Qinwei Xu, Yan Liu, Zhili Hao et autres

BACKGROUND: There is an increase in the global incidence of allergies. The hygiene hypothesis and the old friend hypothesis reveal that helminths are associated with the prevalence of allergic diseases. The therapeutic potential of Trichinella spiralis is recognized; however, the stage at …

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Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

Wenjie Shi, Ning Xu, Xuelin Wang, Mingyuan Liu et autres

Wenjie Shi,1,* Ning Xu,1,* Xuelin Wang,1 Isabelle Vallée,2 Mingyuan Liu,1 Xiaolei Liu1 1Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, People’s Republic of China; 2UMR BIPAR, Anses, INRAE, Ecole Nationale Vétérinaire …

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The immune protection induced by a serine protease from the Trichinella spiralis adult against Trichinella spiralis infection in pigs

Daoxiu Xu, Xue Bai, Jing Xu, Xuelin Wang et autres

Trichinellosis is a major foodborne parasitosis caused by Trichinella spiralis. In the present study, a serine protease gene from an adult T. spiralis (Ts-Adsp) cDNA library was cloned, expressed in Escherichia coli and purified by Ni-affinity chromatography. Previous studies of our laboratory …

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The immune protection induced by a serine protease from the Trichinella spiralis adult administered as DNA and protein vaccine

Daoxiu Xu, Bin Tang, Yang Wang, Lixiao Zhang et autres

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Relationship of Immunoglobulin G Blood Antibodies in Pregnant Women and Hemorrhagic Disease in Newborns

Wenjie Shi