Henrike Zech

Kommentar zu „Oropharynxkarzinom: zirkulierende HPV-DNA als Prognose-Biomarker“

Henrike Zech

10.1055/a-2690-3186 ***Bei Patienten mit HPV-positiven Oropharynxkarzinomen lässt sich nahezu regelhaft zirkulierende HPV-DNA (ctHPV-DNA) im Blut nachweisen. Mehre Studien zeigen das hohe Potenzial der ctHPV-DNA als Marker der Früherkennung, der Prognose und der Detektion von Rezidiven in der Nachsorge [ 1 ]. Die …

Oft unterschätzt: Prävention in der HNO

Stefan Gareis, Friederike Meyer, Henrike Zech

Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells

J. Roehrle, Adriana Perugachi-Heinsohn, Fruzsina Gatzemeier, Sabrina Christiansen et autres

Radiochemotherapy with the apoptosis stimulator xevinapant demonstrated superiority over radiochemotherapy in a randomized phase 2 trial in head and neck squamous cell carcinoma (HNSCC) but the subsequent phase 3 trial failed. Here, we compared the radiosensitization through xevinapant with two other emerging …

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Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann et autres

Complete surgical resection is essential for oropharyngeal squamous cell carcinoma (OPSCC) therapy, underscoring the need for improved intraoperative margin assessment. To advance in vivo diagnostics for OPSCC, Nanosecond infrared laser (NIRL) tissue sampling combined with shotgun lipidomic analysis reveals lipidome differences between …

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Nasopharynxkarzinome – Hoffnungsträger Immuntherapie?

Henrike Zech, Philippe Schafhausen, Christian Betz

Author response for "Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma"

Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann et autres

Discordance Between p16-Expression and HPV-Status in Sinonasal Carcinoma: A Multicenter Retrospective Study

Nina Wenda, Henrike Zech, Marta Barde, Leoni Ramke et autres

BACKGROUND/OBJECTIVES: Human papillomavirus (HPV) infection is a well-established risk factor for oropharyngeal squamous cell carcinoma (OPSCC), where p16 immunohistochemistry serves as a surrogate marker. However, the role of HPV in sinonasal squamous cell carcinoma (SNSCC) remains less defined, and the reliability of …

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Author response for "Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma"

Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann et autres

Infrared Laser Sampling of Low Volumes Reveals Marker Lipids in Palatine Tonsil Carcinoma via Shotgun Lipidomics

Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann et autres

Complete surgical resection is essential for oropharyngeal squamous cell carcinoma (OPSCC) therapy, underscoring the need for improved intraoperative margin assessment. To advance in-vivo diagnostics of OPSCC, Nanosecond infrared laser (NIRL) tissue sampling combined with shotgun lipidomic analysis reveals lipidome differences between OPSCC …

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Nasopharynxkarzinome

Henrike Zech, Christian Betz

Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization

Henrike Zech, Philippe Schafhausen, Leonie Ramke, Janna-Lisa Velthaus et autres

Background/Objectives: In recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), the overall prognosis is poor, and systemic treatment options remain limited. While precision therapy approaches have revolutionized treatment strategies in several tumor types, molecularly informed therapies in R/M HNSCC are rare, …

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UV1 vaccination in pembrolizumab-treated patients with recurrent or metastatic head and neck cancer: A randomized multicenter phase 2 trial

Anna Brandt, Konrad Klinghammer, Christoph Schultheiß, Lisa Paschold et autres

BACKGROUND: Human telomerase reverse transcriptase is highly expressed in head and neck squamous cell carcinoma (HNSCC). The FOCUS study examines the role of the telomerase-directed vaccine UV1 in combination with pembrolizumab in patients with recurrent or metastatic (R/M) HNSCC. METHODS: HNSCC. A …

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