Nicholas P. Deems

Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease

Asmaa Badr, Kylene P. Daily, Mostafa Eltobgy, Shady Estfanous et autres

Neuroinflammation and accumulation of Amyloid Beta (Aβ) accompanied by deterioration of special memory are hallmarks of Alzheimer's disease (AD). Effective preventative and treatment options for AD are still needed. Microglia in AD brains are characterized by elevated levels of microRNA-17 (miR-17), which …

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Post-operative cognitive dysfunction is exacerbated by high-fat diet via TLR4 and prevented by dietary DHA supplementation

Stephanie Muscat, Michael J. Butler, Menaz N. Bettes, James W. DeMarsh et autres

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TLR4 mediates development of persistent post-operative cognitive dysfunction following short-term high-fat diet consumption in male rats

Stephanie Muscat, Michael J. Butler, Nicholas P. Deems, Menaz N. Bettes et autres

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TLR4 mediates development of persistent post-operative cognitive dysfunction following short-term high-fat diet consumption in male rats

Stephanie Muscat, Michael J. Butler, Nicholas P. Deems, Menaz N. Bettes et autres

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Corrigendum to “CD8+ T cells contribute to diet-induced memory deficits in aged male rats” [Brain Behav. Immun. 109 (2023) 235–250]

Michael J. Butler, Shouvonik Sengupta, Stephanie Muscat, Stephanie A. Amici et autres

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CD8+ T cells contribute to diet-induced memory deficits in aged male rats

Michael J. Butler, Shouvonik Sengupta, Stephanie Muscat, Stephanie A. Amici et autres

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Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats

Stephanie Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel Scaria et autres

Perioperative neurocognitive disorders (PNDs) are characterized by confusion, difficulty with executive function, and episodic memory impairment in the hours to months following a surgical procedure. Postoperative cognitive dysfunction (POCD) represents such impairments that last beyond 30 d postsurgery and is associated with …

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The effect of high fat diet on neuroinflammation, synaptic plasticity, and pathology in the 3xTg-AD mouse model

Sabrina Mackey-Alfonso, Alberto R. Williams-Medina, Michael Bütler, Nicholas P. Deems et autres

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TLR4 antagonism prevents & reverses opiate-induced persistent post-operative cognitive dysfunction in aged male rats

Stephanie Muscat, Nicholas P. Deems, Emmanuel Scaria, Michael J. Butler et autres

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Short-term consumption of a high-fat diet makes post-operative cognitive dysfunction persistent & induces anxiety-like behaviors in aged male rats

Stephanie Muscat, Nicholas P. Deems, Michael J. Butler, Ruth M. Barrientos

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Postoperative Cognitive Dysfunction: Factors beyond neuroinflammation

Nicholas P. Deems, Emmanuel Scaria, Michael Bütler, Stephanie Muscat et autres

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Short-term high fat diet consumption impairs learning and memory and increases CNS T cell populations in aged male rats

Michael Butler, Shouvonik Sengupta, Nicholas P. Deems, Stephanie A. Amici et autres

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