Ruth M. Barrientos

Targeting neuroinflammation and mitochondrial dysfunction in postoperative cognitive dysfunction: A review of potential integrative medicine approaches

Allegra Tannoury, Navya H. Garg, Zoha H. Khan, Jayden D. Milligan et autres

Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats

Stephanie Muscat, Nicholas P. Deems, Bryan D. Alvarez, Michael J. Butler et autres

Postoperative cognitive dysfunction (POCD) is a common and persistent complication in aging individuals following surgery, particularly when opioids are used for perioperative pain management. Although opioids are widely administered in the perioperative setting, the mechanisms by which they contribute to long-term cognitive …

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Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats

Stephanie Muscat, N.P. Deems, Bryan D. Alvarez, Michael J Butler et autres

Postoperative cognitive dysfunction (POCD) is a common and persistent complication in aging individuals following surgery, particularly when opioids are used for perioperative pain management. Although opioids are widely administered in the perioperative setting, the mechanisms by which they contribute to long-term cognitive …

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Short-term high-fat diet impairs anterograde and retrograde memory consolidation, but not retrieval in aged rats

Bryan D. Alvarez, Jayden D. Milligan, Zoha H. Khan, Ruth M. Barrientos

BACKGROUND: Aging increases vulnerability to cognitive decline, and ultraprocessed diets high in saturated fat may accelerate this trajectory. Although short-term high-fat diet (HFD) exposure is known to impair memory in aged animals, the specific stages of memory most susceptible to short-term HFD …

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The aged amygdala’s unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis

Michael Bütler, Jade Blackwell, Hannah F Sanders, Dominic Kolonay et autres

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Neuroinflammatory mechanisms linking high‐fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis

Sabrina Mackey-Alfonso, Ruth M. Barrientos

As global life expectancy increases, Alzheimer's disease (AD) incidence is rising rapidly. While research has long focused on amyloid beta (Aβ) and tau pathology, recent controversies and limited clinical success of Aβ-targeting therapies have challenged their centrality in AD. Emerging evidence highlights …

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AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

Heba M. Amer, Mohamed M. Shamseldin, Sarah Faber, Mostafa Eltobgy et autres

Long COVID (LC) following SARS-CoV-2 infection affects millions of individuals world-wide and manifests with a variety of symptoms including cognitive dysfunction also known as "brain fog". This is characterized by difficulties in executive functions, planning, decision-making, working memory, impairments in complex attention, …

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Dr. Steven F. Maier: A fearless scientist, a rigorous mentor, and a legacy of excellence

Ruth M. Barrientos, Michael V. Baratta, Matthew G. Frank

For more than 40 years, Dr. Steven F. Maier has shaped the field of psychoneuroimmunology through innovative research, influential mentorship, and dedicated service to the scientific community. As he concludes his tenure as Associate Editor of Brain, Behavior, and Immunity, this tribute …

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Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology

Daniela Jimenez-Harrison, Michael Bütler, Haanya Ijaz, Rami Alsabbagh et autres

A growing body of literature has identified periodontal disease among the modifiable risk factors for Alzheimer's disease (AD), but the mechanisms underlying this relationship is unknown. This study investigated this relationship using a ligature-induced preclinical periodontitis (Pd) model in non-transgenic (non-Tg) and …

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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats

Michael Bütler, Stephanie Muscat, Maria Elisa Caetano‐Silva, Akriti Shrestha et autres

BACKGROUND: Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory function via a neuroinflammatory mechanism. However, the degree to which …

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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats

Stephanie Muscat, Michael J. Butler, Akriti Shresthra, Maria Elisa Caetano‐Silva et autres

The influence of TLR4 mediated neuroinflammation and the complement system on HFD-evoked memory impairments in an AD mouse model

Sabrina Mackey-Alfonso, Jade Blackwell, Ruth M. Barrientos