Rian Roelofs

No replicating evidence for anti‐amyloid‐β autoantibodies in cerebral amyloid angiopathy‐related inflammation

Emma van den Berg, Rian Roelofs, Lieke Jäkel, Steven Mark Greenberg et autres

OBJECTIVE: Elevated levels of anti-amyloid-β (anti-Aβ) autoantibodies in cerebrospinal fluid (CSF) have been proposed as a diagnostic biomarker for cerebral amyloid angiopathy-related inflammation (CAA-RI). We aimed to independently validate the immunoassay for quantifying these antibodies and evaluate its diagnostic value for CAA-RI. …

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Erythropoiesis–hepcidin–iron axis in patients with X‐linked sideroblastic anaemia: An explorative biomarker study

Vera Hoving, Lieke E. Nijssen, Albertine E. Donker, Rian Roelofs et autres

Contains fulltext : 296529.pdf (Publisher’s version ) (Open Access)

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Supplementary Table 1 from Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients

Annemarie Boleij, Rian Roelofs, Camille Danne, Samuel Bellais et autres

PDf file - 79K

Supplementary Table 1 from Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients

Annemarie Boleij, Rian Roelofs, Camille Danne, Samuel Bellais et autres

PDf file - 79K

Data from Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients

Annemarie Boleij, Rian Roelofs, Camille Danne, Samuel Bellais et autres

Abstract Streptococcus gallolyticus subsp. gallolyticus (previously called Streptococcus bovis biotype I) infections have long been associated with colorectal cancer (CRC). This work aimed to investigate the CRC-associated humoral immune response to four pilus proteins of this bacterium by newly developed ELISAs. Pilus …

Data from Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients

Annemarie Boleij, Rian Roelofs, Camille Danne, Samuel Bellais et autres

Abstract Streptococcus gallolyticus subsp. gallolyticus (previously called Streptococcus bovis biotype I) infections have long been associated with colorectal cancer (CRC). This work aimed to investigate the CRC-associated humoral immune response to four pilus proteins of this bacterium by newly developed ELISAs. Pilus …

Investigating the Molecular Mechanisms of Renal Hepcidin Induction and Protection upon Hemoglobin-Induced Acute Kidney Injury

Laura E. Diepeveen, Gaby Stegemann, Erwin T. G. Wiegerinck, Rian Roelofs et autres

Hemolysis is known to cause acute kidney injury (AKI). The iron regulatory hormone hepcidin, produced by renal distal tubules, is suggested to exert a renoprotective role during this pathology. We aimed to elucidate the molecular mechanisms of renal hepcidin synthesis and its …

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Kidney tubule iron loading in experimental focal segmental glomerulosclerosis

Rachel P. L. van Swelm, Sanne Beurskens, Henry B P M Dijkman, Erwin T. G. Wiegerinck et autres

Kidney iron deposition may play a role in the progression of tubulointerstitial injury during chronic kidney disease. Here, we studied the molecular mechanisms of kidney iron loading in experimental focal segmental glomerulosclerosis (FSGS) and investigated the effect of iron-reducing interventions on disease …

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Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells

Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu et autres

Objective The opportunistic pathogen Streptococcus gallolyticus is one of the few intestinal bacteria that has been consistently linked to colorectal cancer (CRC). This study aimed to identify novel S. gallolyticus-induced pathways in colon epithelial cells that could further explain how S. gallolyticus …

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Differentiating iron-loading anemias using a newly developed and analytically validated ELISA for human serum erythroferrone

Laura E. Diepeveen, Rian Roelofs, Nicolaï Grebenchtchikov, Rachel van Swelm et autres

Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis. ERFE plays a pathological role during ineffective erythropoiesis as occurs in X-linked sideroblastic anemia (XLSA) and β-thalassemia. Its measurement might serve as an indicator of severity …

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Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn P. A. Hoeks, Timothy Bagguley, Corine van Marrewijk, Alex G. Smith et autres

Red blood cell transfusions (RBCT) remain the cornerstone of supportive care in lower-risk myelodysplastic syndrome (LRMDS) [ 1 ]. Transfusion dependency in LRMDS patients is associated with inferior outcomes, mainly attributed to severe bone marrow failure [ 2 ]. However, iron toxicity, …

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Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer

Julia Butt, Nerea Fernández de Larrea, Harold Tjalsma, Rian Roelofs et autres

Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC …

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