Accès ouvert
2022
article
OpenAlex
Laura E. Diepeveen, Gaby Stegemann, Erwin T. G. Wiegerinck, Rian Roelofs et autres
Hemolysis is known to cause acute kidney injury (AKI). The iron regulatory hormone hepcidin, produced by renal distal tubules, is suggested to exert a renoprotective role during this pathology. We aimed to elucidate the molecular mechanisms of renal hepcidin synthesis and its …
nl, us, fr, de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Laura E. Diepeveen, Rian Roelofs, Nicolaï Grebenchtchikov, Rachel van Swelm et autres
Erythroferrone (ERFE), the erythroid regulator of iron metabolism, inhibits hepcidin to increase iron availability for erythropoiesis. ERFE plays a pathological role during ineffective erythropoiesis as occurs in X-linked sideroblastic anemia (XLSA) and β-thalassemia. Its measurement might serve as an indicator of severity …
nl, fr
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Margreet Kouwenberg, Wilco P. C. Pulskens, Laura E. Diepeveen, M.A.H. Bakker-van Bebber et autres
The dendritic cell (DC)-derived cytokine profile contributes to naive T cell differentiation, thereby directing the immune response. IL-37 is a cytokine with anti-inflammatory characteristics that has been demonstrated to induce tolerogenic properties in DC. In this study we aimed to evaluate the …
nl, us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Ellis T. Aune, Laura E. Diepeveen, Coby M. Laarakkers, Siem M. Klaver et autres
Objectives: Hepcidin measurement advances insights in pathophysiology, diagnosis, and treatment of iron disorders, but requires analytically sound and standardized measurement procedures (MPs). Recent development of a two-level secondary reference material (sRM) for hepcidin assays allows worldwide standardization. However, no proficiency testing (PT) …
nl, gb, ca, be, us, fi, pl, fr, ch, de, jp
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Margreet Kouwenberg, Angelique L. W. M. M. Rops, Marinka Bakker-van Bebber, Laura E. Diepeveen et autres
Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models. Sdc-1 expression has been reported on dendritic cells (DC) and T cells. The potential role of …
nl, de
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Margreet Kouwenberg, Angelique L. W. M. M. Rops, Marinka Bakker-van Bebber, Laura E. Diepeveen et autres
Abstract Syndecan-1 (Sdc-1) is a heparan sulfate proteoglycan that can bind cytokines and chemokines via its heparan sulfate side chains, and has immunomodulatory properties in experimental models. Sdc-1 expression has been reported on dendritic cells (DC) and T cells. The potential role …
nl, de
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Laura E. Diepeveen, Coby M. Laarakkers, Hilde P.E. Peters, Antonius Eduard van Herwaarden et autres
Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%. Since protein-binding may influence hormone function and quantification, …
nl
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Laura E. Diepeveen, Coby M. Laarakkers, Gustavo Martos, Marta E. Pawlak et autres
Background Hepcidin concentrations measured by various methods differ considerably, complicating interpretation. Here, a previously identified plasma-based candidate secondary reference material (csRM) was modified into a serum-based two-leveled sRM. We validated its functionality to increase the equivalence between methods for international standardization. Methods …
nl, fr, us, gb, de, be, it, fi, jp
(code pays fourni par la source)