M Havlová

Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia

Francesco Leonetti, Sladjana Kosanovic, R. R. Rios, Iris Manosalva et autres

Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the clonal proliferation of undifferentiated myeloid precursors in the bone marrow. Although standard induction regimens based on anthracyclines often achieve initial remission, up to 25% of patients exhibit primary refractory …

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Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard chromatin fiber integrity. In Drosophila, the chromodomain protein MSL3 binds H3K36me3 at X-chromosomal genes to implement dosage compensation. The …

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RETRACTED AND REPLACED: Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard the integrity of the chromatin fiber. The chromodomain protein MSL3 binds H3K36me3 to target X-chromosomal genes in male Drosophila …

de, pl, cz (code pays fourni par la source)

Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Abstract Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard the integrity of the chromatin fiber. The chromodomain protein MSL3 binds H3K36me3 to target X-chromosomal genes in male …

de, cz (code pays fourni par la source)

Mosaicism for GJB1 mutation causes milder Charcot-Marie-Tooth X1 phenotype in a heterozygous man than in a manifesting heterozygous woman

Irena Borgulová, Radim Mazanec, Iva Sakmaryová, M Havlová et autres

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113. Therapeutic benefit of intravenous immunoglobulin found in patient with POEMS syndrome

Lucie Nováková, P. Jiroutek, Johann Böhm, M Havlová et autres

114. Coexistence of spinal muscular atrophy and amyotrophic lateral sclerosis within a single family

Lucie Nováková, M Havlová, Johann Böhm, P. Jiroutek et autres

[Alternating hemiplegia of childhood (AHC)].

Soňa Nevšímalová, M Havlová, Alena Tauberová, Iva Příhodová

BACKGROUND: Alternating hemiplegia of childhood (AHC) is a rare neurological disease of unknown aetiology characterized by recurrent paroxysmal attacks of side-alternating hemiplegias of variable duration associated with other paroxysmal dysfunctions. Paroxysmal attacks start in infants but neurological deficits become progressive with the …

[Cardiac problems in patients with progressive muscular dystrophy].

Danzig, Jan Fiksa, M Havlová, Karel Šonka

Progressive muscular dystrophy causes both skeletal and significant cardiological changes. Electrocardiographic and echocardiographic examinations were provided in 30 patients with muscular dystrophy (17 of them with progressive muscular dystrophy Duchenne type, 13 with skeletal muscular dystrophy). In 50% cases were found left …

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194 Congenital myasthenic syndrome with myopathic features in a gipsy population

И.И. Степанова, M Havlová, Soňa Nevšímalová

[Nonstandard therapy of epileptics and psychotics].

Jean Faber, M Havlová

The authors present their experience with a number of drugs which are not antiepileptics nor antipsychotic drugs but influence the cholinergic and noradrenergic system and glucose and protein metabolism of neurons. Their efficiency in severe epileptics with psychic changes is about 60%. …

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Syndrome of secondary polymyositis with leukemia.

Jan Starý, S Havelka, O Hrodek, P Vavrincová et autres

A boy with neurofibromatosis suffered mumps at the age of 5. A full-blown juvenile polymyositis developed shortly afterwards. First hematological consultation was done for monocytosis in peripheral blood at the age of 7. He suffered varicella at the age of 8. Diagnosis …

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