Catherine Regnard

PWWP mutants of the transcriptional cofactor JASPer divert promoter and enhancer activities and suppress position effect variegation in Drosophila

Derek Atkinson, Karolina Barucka, Lisa Jerabek, Francesco Cardamone et autres

Su(var) genes regulate the formation and maintenance of heterochromatin in Drosophila melanogaster , yet how factors associated with active chromatin influence heterochromatin stability remains poorly understood. Through a new genetic Su(var) screen, we identified two strong suppressors of position effect variegation that …

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Developmental regulation of Drosophila dosage compensation in a 3D genome context

Lubna Younas, Mujahid Ali, Xinpei Zhang, Catherine Regnard et autres

Abstract Chromosomal dosage compensation (DC) restores the expression balance of X chromosome between sexes, and is realised in Drosophila by the coordination of enriched X-linked PionX, HAS sequence elements and 1.688 3F satellites, resulting in doubling the transcription of X-linked genes in …

at, cn, de, gb (code pays fourni par la source)

Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard chromatin fiber integrity. In Drosophila, the chromodomain protein MSL3 binds H3K36me3 at X-chromosomal genes to implement dosage compensation. The …

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RETRACTED AND REPLACED: Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard the integrity of the chromatin fiber. The chromodomain protein MSL3 binds H3K36me3 to target X-chromosomal genes in male Drosophila …

de, pl, cz (code pays fourni par la source)

Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers

Muhunden Jayakrishnan, M Havlová, Václav Veverka, Catherine Regnard et autres

Abstract Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is interpreted by epigenetic readers that assist transcription and safeguard the integrity of the chromatin fiber. The chromodomain protein MSL3 binds H3K36me3 to target X-chromosomal genes in male …

de, cz (code pays fourni par la source)

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila

Christian Albig, Chao Wang, Geoffrey P. Dann, Felix Wojcik et autres

In flies, the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, such as dimethylated histone H3K9 (H3K9me2) and HP1. Here, we show that JIL-1's targeting to chromatin …

de, us, cn, fr (code pays fourni par la source)

Progressive dosage compensation during Drosophila embryogenesis is reflected by gene arrangement

Khairunnadiya Prayitno, Tamás Schauer, Catherine Regnard, Peter B. Becker

us, de (code pays fourni par la source)

JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila

Christian Albig, Chao Wang, Geoffrey P. Dann, Felix Wojcik et autres

Abstract In flies, the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, like dimethylated histone H3K9 (H3K9me2) and HP1. Here, we show that JIL-1’s targeting to chromatin …

de, us, fr (code pays fourni par la source)

Factor cooperation for chromosome discrimination in Drosophila

Christian Albig, Е. А. Тихонова, Silke Krause, Oksana Maksimenko et autres

Transcription regulators select their genomic binding sites from a large pool of similar, non-functional sequences. Although general principles that allow such discrimination are known, the complexity of DNA elements often precludes a prediction of functional sites. The process of dosage compensation in …

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PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

Stephanie Link, Ramona M. M. Spitzer, Maryam Sana, Mario Torrado et autres

Chromatin structure and function is regulated by reader proteins recognizing histone modifications and/or histone variants. We recently identified that PWWP2A tightly binds to H2A.Z-containing nucleosomes and is involved in mitotic progression and cranial-facial development. Here, using in vitro assays, we show that …

de, au, us, gb (code pays fourni par la source)

Factor cooperation for chromosome discrimination in Drosophila

Christian Albig, Е. А. Тихонова, Silke Krause, Oksana Maksimenko et autres

Abstract Transcription regulators select their genomic binding sites from a large pool of similar, non-functional sequences. Although general principles that allow such discrimination are known, the complexity of DNA elements often precludes a prediction of functional sites. The process of dosage compensation …

de, ru (code pays fourni par la source)

Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation

Tamás Schauer, Yad Ghavi-Helm, Tom Sexton, Christian Albig et autres

de, fr (code pays fourni par la source)