Fabienne Laugerette

Comparison of antioxidant efficiencies in oil‐in‐water emulsion using extracellular vesicles from olive co‐products or liposomes as antioxidants carriers

Bruno Baréa, Nathalie Barouh, Amal Fenaghra, Pascal Colosetti et autres

Abstract Olive extracellular vesicles and synthetic liposomes were evaluated as carriers of antioxidants to stabilize oil‐in‐water emulsions against oxidative degradation. For this, hydroxytyrosol, rosmarinic acid and their lipophilic counterparts, (hydroxytyrosyl dodecanoate esters or eicosyl rosmarinate esters) were loaded into these carrier vesicles …

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Postprandial lipid and vascular responses following consumption of a commercially-relevant interesterified palmitic acid-rich spread in comparison to functionally-equivalent non-interesterified spread and spreadable butter: a randomised controlled trial in healthy adults

Wendy Louise Hall, Aseel Alkoblan, Philippa S. Gibson, Maria Letizia D’Annibale et autres

: In healthy adults, a commercially-available IE-based spread did not evoke a different postprandial triacylglycerol, lipoprotein subclass, oxidative stress, inflammatory or endotoxemic response to functionally-equivalent, but compositionally-distinct alternative spreads. Clinical trial registry number: NCT03438084 (https://ClinicalTrials.gov).

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Inhibition of intestinal FXR activity as a possible mechanism for the beneficial effects of a probiotic mix supplementation on lipid metabolism alterations and weight gain in mice fed a high fat diet

Alice Beau, Bérengère Benoit, Mélanie Le Barz, Emmanuelle Meugnier et autres

LA806 on high-fat (HF) diet -induced metabolic disease in mice. Supplementation with the probiotic mix in HF diet-fed mice (HF-Pr2) reduced weight and fat mass gains, decreased hepatic lipid accumulation, and lowered plasma triglyceride peak during an oral lipid tolerance test. At …

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Soy Lecithin in High‐Fat Diets Exerts Dual Effects on Adipose Tissue Versus Ileum

Charline Buisson, Valentin Leuzy, Emmanuelle Loizon, Emmanuelle Meugnier et autres

SCOPE: Lipopolysaccharides and their transporters, LBP and sCD14, are involved in systemic inflammation following a high-fat diet. Natural emulsifiers such as soy lecithin, rich in soybean polar lipids (SPL), are often used by the food industry but little is known about effects …

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A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs

Ahmed Ben Mohamed, Didier Rémond, Andreu Gual‐Grau, Annick Bernalier-Donnadille et autres

This study evaluates the capacity of a bread enriched with fermentable dietary fibres to modulate the metabolism and nutrients handling between tissues, gut and peripheral, in a context of overfeeding. Net fluxes of glucose, lactate, urea, short chain fatty acids (SCFA), and …

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Impact of Rapeseed and Soy Lecithin on Postprandial Lipid Metabolism, Bile Acid Profile, and Gut Bacteria in Mice

Chloé Robert, Charline Buisson, Fabienne Laugerette, Hélène Abrous et autres

SCOPE: Synthetic emulsifiers have recently been shown to promote metabolic syndrome and considerably alter gut microbiota. Yet, data are lacking regarding the effects of natural emulsifiers, such as plant lecithins rich in essential α-linolenic acid (ALA), on gut and metabolic health. METHODS …

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Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion

Fabienne Laugerette, Cécile Vors, Maud Alligier, Gaëlle Pineau et autres

Circulating levels of lipopolysaccharide-binding protein (LBP) and soluble cluster of differentiation 14 (sCD14) are recognized as clinical markers of endotoxemia. In obese men, postprandial endotoxemia is modulated by the amount of fat ingested, being higher compared to normal-weight (NW) subjects. Relative variations …

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Differential metabolic impact of natural food-grade emulsifiers rich in α-linolenic acid in rodents

Chloé Robert, Charline Buisson, Leslie Couëdelo, Emmanuelle Meugnier et autres

International audience

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Differential Metabolic Impact of Natural Food-Grade Emulsifiers Rich in Alpha-Linolenic Acid

Chloé Robert, Charline Buisson, Leslie Couëdelo, Emmanuelle Meugnier et autres

Dietary synthetic emulsifiers have recently been shown to promote metabolic syndrome and considerably alter gut microbiota. Conversely, natural emulsifiers such as milk polar lipids (PL) are associated with beneficial metabolic effects. The effects of plant PL remain, however, poorly described. Our objective …

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Impact of vegetable lecithin on lipid metabolism and the bioavailability of alpha-linolenic acid in rodents

Chloé Robert, Charline Buisson, Leslie Couëdelo, Carole Knibbe et autres

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Extracellular vesicles from olive co-products: Isolation, characterization and antioxidant activity

Amal Fenaghra, Pascal Colosetti, Jérôme Lecomte, Bruno Baréa et autres

Extracellular vesicles (EVs) are nanoscopic membranous structures which are involved in intercellular communication between cells and could have interesting antioxidant/antiinflammatory properties. Recent works highlighted the existence of EVs secreted by plant cells. The objective of our study, is to characterize the main …

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Impact of the addition of vegetable lecithin in oil on lipid metabolism and the bioavailability of an essential fatty acid: alpha-linolenic acid

Chloé Robert, Charline Buisson, Emmanuelle Meugnier, Emmanuelle Loizon et autres

International audience

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