Alice Beau

Pregnane X receptor deletion induces a lean phenotype in chow-fed mice through a liver–ileum–muscle axis involving 6α-hydroxylated bile acids and Fgf15

Bérengère Benoit, Audrey Jalabert, Emmanuelle Meugnier, Stéphanie Chanon et autres

ABSTRACT Objectives The pregnane X receptor (Pxr; Nr1i2 ) plays a role in metabolic regulation. However, its contribution to systemic energy homeostasis under physiological conditions remains unclear. Here, we investigated the metabolic consequences of Nr1i2 deficiency in chow-fed mice. Methods Phenotyping was …

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Lactiplantibacillus plantarum WJL ameliorates chronic kidney disease by inhibiting fibroblast growth factor 21 adaptive stress response via low protein diet

Bérengère Benoit, Pierre Letourneau, Vincent Verdier, Angelique Viney et autres

Low-protein diets (LPD) are recommended in chronic kidney disease (CKD) to reduce disease progression. However, their clinical efficacy and safety are debated due to the risk of protein-energy wasting. A deeper mechanistic understanding is therefore required. Herein, the metabolic effects of LPD …

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Digestates of pea and fava bean proteins induce FGF19 in human intestinal HT29 cells: Evidence for a potential role of PPARγ

Bérengère Benoit, Clémence Defois-Fraysse, Audrey Jalabert, Sandra Pesenti et autres

Plant-based proteins are promising alternatives to animal proteins for supporting muscle synthesis and preventing sarcopenia. This study examined whether protein digestates (PDs) from pea and fava bean isolates modulate intestinal Fibroblast Growth Factor 19 (FGF19), a hormone central to energy and muscle …

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Therapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice

Hao Zhang, Priyanka Garg, Bérengère Benoit, Claudie Pinteur et autres

Osteosarcopenia, characterized by the coexistence of osteopenia/osteoporosis and sarcopenia, represents a significant health concern in geriatrics, with an increased risk of falls and fractures. The enterokine fibroblast growth factor 19 (FGF19) was recently shown to prevent muscle weakness in preclinical models. This …

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A specifically designed multi-biotic reduces uremic toxin generation and improves kidney function

Alice Beau, Jane M. Natividad, Bérengère Benoit, Philippe Delerive et autres

Chronic kidney disease (CKD) is characterized by accumulation of uremic toxins (UTs), such as p-cresyl sulfate and indoxyl sulfate, generated through the transformation of tyrosine and tryptophan by the gut microbiota. Using an ex vivo Simulator of the Human Intestinal Microbial Ecosystem …

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Inhibition of intestinal FXR activity as a possible mechanism for the beneficial effects of a probiotic mix supplementation on lipid metabolism alterations and weight gain in mice fed a high fat diet

Alice Beau, Bérengère Benoit, Mélanie Le Barz, Emmanuelle Meugnier et autres

LA806 on high-fat (HF) diet -induced metabolic disease in mice. Supplementation with the probiotic mix in HF diet-fed mice (HF-Pr2) reduced weight and fat mass gains, decreased hepatic lipid accumulation, and lowered plasma triglyceride peak during an oral lipid tolerance test. At …

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A probiotic supplementation prevents lipid metabolism alterations and limits weight gain possibly via inhibition of intestinal FXR activity in mice fed a high fat diet

Alice Beau, Bérengère Benoit, Mélanie Le Barz, Claudie Pinteur et autres

International audience

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Indoxyl sulfate inhibits muscle cell differentiation via Myf6/MRF4 and MYH2 downregulation

Stanislas Bataille, Nathalie McKay, Laetitia Koppe, Alice Beau et autres

BACKGROUND: Chronic kidney disease (CKD) is associated with a significant decrease in muscle strength and mass, possibly related to muscle cell damage by uremic toxins. Here, we studied in vitro and in vivo the effect of indoxyl sulfate (IS), an indolic uremic …

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#3454 IMPACT OF SYMBIOTICS ON UREMIC TOXINS PRODUCTION, RENAL FUNCTION AND PEW SYNDROME IN SHIME AND CKD MICE MODELS

Alice Beau, Bérengère Benoit, Marie Jammes, Claudie Pinteur et autres

Abstract Background and Aims Alterations in gut microbiota in CKD patients have been linked to CKD progression, cachexia, and mortality. Gut dysbiosis is associated by modification of gut-microbiota-derived metabolites, including a decrease of short-chain fatty acids (SCFAs), an increase in gut-derived uremic …

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Treatment with fibroblast growth factor 19 increases skeletal muscle fiber size, ameliorates metabolic perturbations and hepatic inflammation in 5/6 nephrectomized mice

Bérengère Benoit, Alice Beau, Émilie Bres, Stéphanie Chanon et autres

Chronic kidney disease (CKD) is associated with osteosarcopenia, and because a physical decline in patients correlates with an increased risk of morbidity, an improvement of the musculoskeletal system is expected to improve morbi-mortality. We recently uncovered that the intestinal hormone Fibroblast Growth …

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Hypersensibilité hypothalamique au glucose du rat Zücker obèse, insulino-résistant et hypoghrélinémique: restauration de la sécrétion dâinsuline via lâactivité de lâaxe hypothalamo-pancréatique par un prétraitement cérébral à la ghréline.

Alice Beau, Fabienne Liénard, Claire Fenech, Sylvie Grall et autres

Hypersensibilité hypothalamique au glucose du rat Zücker obèse, insulino-résistant et hypoghrélinémique: restauration de la sécrétion d’insuline via l’activité de l’axe hypothalamo-pancréatique par un prétraitement cérébral à la ghréline.

Alice Beau, Fabienne Liénard, Claire Fenech, Sylvie Grall et autres