Frederik Lars Giesel

An auxiliary 18F-FDG uptake pattern clarifying equivocal adrenal gland mass after dual-tracer imaging with 123I-mIBG SPECT/CT and 18F-FDG PET/CT.

E Novruzov, Sandra Jaschinski, Iréne Esposito, Gerald Antoch et autres

Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors arising from the adrenal medulla. Several studies have reported activation of brown adipose tissue (BAT) in up to 30% of patients with pheochromocytoma. Brown adipose tissue is characterized by abundant mitochondria to provide heat generation rather …

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Regionale Zusammenhänge zwischen der Reduktion des endogenen Dopamingehalts und der funktionalen Konnektivität im Gehirn der Ratte

Susanne Nikolaus, H-J Wittsack, Markus Beu, Julia Henke et autres

Ziel/Aim: Die funktionelle MRT im Ruhezustand (rs-fMRT) ermöglicht die Untersuchung der funktionalen Konnektivität (rs-FK) auf der Grundlage der BOLD-Signale. Eine Bedingung für Veränderungen der rs-FC sind Veränderungen der Neurotransmitterkonzentrationen. GABA ist der wichtigste inhibitorische Neurotransmitter. In dieser Pilotstudie untersuchten wir den Einfluss …

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Clinical Evaluation of a New Automated Bridge Assay for the Detection of Thyroid-Stimulating Hormone Receptor Autoantibodies

Patricia Schott-Ohly, Samer Albeiruty, Mareike Muchalla, U Doetter et autres

Graves' disease is an autoimmune disease caused by autoantibodies to the thyroid-stimulating hormone receptor, which usually leads to hyperthyroidism in these patients. The aim of the present study was to evaluate a new automated bridge chemiluminescence thyroid-stimulating hormone receptor autoantibody assay for …

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Dose-dependent cytotoxic profiling of astatine-211 for targeted alpha therapy

Jumpei Ueno, Masayuki Takamatsu, Koki Mayusumi, Atsushi Shimoyama et autres

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Current status of FAP therapy in solid tumors

Sophie Carina Kunte, Emil Novruzov, Eduards Mamlins, Yuriko Mori et autres

FAP-ligands as novel cancer radiopharmaceuticals in nuclear medicine have been recently translated successfully into the clinical space. Particularly small molecules (i.e. FAPI-46, FAPI-74) and peptides (i.e. FAP-2286, DOTAGA.SA.FAPi) seem to be some of the most promising molecular probes for imaging and therapy. …

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A Milestone in Clinical FAPI PET: High Accuracy of [⁶⁸Ga]Ga-FAPI-46 PET/CT in a Prospective Phase 2 Trial

Yuriko Mori, Frederik Lars Giesel

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The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management

Frederik Lars Giesel, Stefan Alexander Koerber, Boris Alexander Hadaschik, Selina Kiefer et autres

Abstract Purpose Clinically accurate detection of prostate cancer (PCa) metastases is crucial for management of high-risk PCa patients scheduled for radical prostatectomy. We determine the safety and diagnostic accuracy of pre-operative 68 Ga-PSMA-11 PET/CT imaging in newly diagnosed high-risk PCa and assess …

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5-HT1A receptor antagonism decreases motor activity and influences dopamine and serotonin metabolization pathways, primarily in cingulate cortex and striatum

Benedetta Fazari, Susanne Nikolaus, Owen Yuan-Hsin Chao, Filipe Rodrigues Almeida et autres

receptor (R) antagonist WAY100,635 on motor behaviors, object place learning and the regional levels of dopamine (DA), serotonin (5-HT) and their metabolites in the rat brain. After a single dose of either WAY100,635 (0.4 mg/kg) or vehicle (0.9% NaCl), recognition memory was …

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Diagnostic utility of FDG and FAPI PET imaging in crohn’s disease: a systematic review and meta-analysis

Ahmed Saad Abdlkadir, Zaid SM Ardalan, Andrew Mark Scott, Hazem T Hammad et autres

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Synthesis and Evaluation of Astatine-211-Labeled Fibroblast activation protein inhibitors

Masayuki Takamatsu, Atsushi Shimoyama, Ayako Aso, Jumpei Ueno et autres

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Value of Additional Systematic Cores During Magnetic Resonance Imaging–guided Targeted Biopsy in Prostate Cancer Screening for Young Men: Results from the PROBASE Trial

Rouvier Al‐Monajjed, Matthias Boschheidgen, Jale Lakes, Agnė Krilavičiūtė et autres

BACKGROUND AND OBJECTIVE: While magnetic resonance imaging (MRI)-guided targeted biopsy (TBx) is becoming an integral part of early detection of prostate cancer (PC), its role in screening of younger men remains unclear. We analyzed the additional value of systematic biopsy (SBx) in …

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Dose-Dependent Cytotoxic Profiling of Astatine-211 for Targeted Alpha Therapy

Jumpei Ueno, Masayuki Takamatsu, Koki Mayusumi, Atsushi Shimoyama et autres

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