Koki Mayusumi

Radioactivity- and time-dependent cellular cytotoxicity of astatine-211-labeled FAP-targeting radiopharmaceuticals

Masayuki Takamatsu, Jumpei Ueno, Taketo Toda, Atsushi Shimoyama et autres

Abstract Fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts (CAFs) is an attractive stromal target for a-therapy. We previously reported moderate anti-tumor effects of 211 At-labeled FAP inhibitors (FAPI) in a PANC-1 xenograft mouse model, where insufficient tumor accumulation and …

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Dose-Time-Dependent Cellular Cytotoxicity of Astatine-211-Labeled FAP-Targeting Radiopharmaceuticals

Masayuki Takamatsu, Jumpei Ueno, Taketo Toda, Atsushi Shimoyama et autres

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A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

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Dose-dependent cytotoxic profiling of astatine-211 for targeted alpha therapy

Jumpei Ueno, Masayuki Takamatsu, Koki Mayusumi, Atsushi Shimoyama et autres

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A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

Synthesis and Evaluation of Astatine-211-Labeled Fibroblast activation protein inhibitors

Masayuki Takamatsu, Atsushi Shimoyama, Ayako Aso, Jumpei Ueno et autres

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Dose-Dependent Cytotoxic Profiling of Astatine-211 for Targeted Alpha Therapy

Jumpei Ueno, Masayuki Takamatsu, Koki Mayusumi, Atsushi Shimoyama et autres

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De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins

Ayane Miura, Yoshiyuki Manabe, Kenichi G. N. Suzuki, Hiroki Shomura et autres

Glycans cover the cell surface to form the glycocalyx, which governs a myriad of biological phenomena. However, understanding and regulating glycan functions is extremely challenging due to the large number of heterogeneous glycans that engage in intricate interaction networks with diverse biomolecules. …

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シンキアルファセンカクシュヒョウシキブンシノソウセイトガンメンエキリョウホウヘノテンカイ

功樹 黛, Koki Mayusumi