Accès ouvert
2026
article
OpenAlex
Shuji Kawaguchi, Kazuhiro Sonomura, Koko Ishizuka, Fumihiko Matsuda et autres
Metabolic alterations in early-stage psychosis may provide insights into disease pathophysiology and potential biomarkers. We performed targeted metabolomic and lipidomic profiling of plasma samples from 31 patients with early-stage psychosis (onset within 24 months) and 22 healthy controls using a liquid chromatography-mass …
jp, us
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Accès ouvert
2026
article
OpenAlex
Travis E. Faust, Atsushi Saito, S Ishikawa, Kun Yang et autres
A fundamental but unanswered question in neuropsychiatry is whether the psychiatric symptoms of epilepsy are caused by the same or a separate pathophysiology as seizures. To address this question, we investigated a monogenic form of epilepsy (pyridoxine-dependent epilepsy) caused by aldehyde dehydrogenase …
us, de
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Accès ouvert
2026
article
OpenAlex
Atsushi Saito, Stephanie Tankou, Kazuhiro Ishii, Makiko Sakao-Suzuki et autres
Congenital cytomegalovirus (CMV) infection is the most common perinatal infection, affecting up to 0.5% of infants. This elicits long-term disabilities that include neuropsychiatric manifestations, such as intellectual disability, microcephaly. Despite its high prevalence, the underlying mechanism of how congenitally acquired CMV infection …
us, jp, gb, de
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Accès ouvert
2025
preprint
OpenAlex
Atsushi Saito, Stephanie Tankou, Kazuhiro Ishii, Makiko Sakao‐Suzuki et autres
Congenital CMV infection is the most common perinatal infection, affecting up to 0.5% of infants. This elicits long-term disabilities that include neuropsychiatric manifestations, such as intellectual disability, microcephaly. Despite its high prevalence, the underlying mechanism of how congenitally acquired CMV infection causes …
us, jp, gb, de
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Accès ouvert
2025
article
OpenAlex
Koko Ishizuka, Arisa Hayashida, Kota Sueo, Akira Sawa
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known as a moonlighting protein beyond its original glycolytic function. Stress-induced nuclear translocation of GAPDH has been reproducibly reported, which results in variety types of cellular responses, including cell death and dysfunction. Blocking this stress-induced cascade has …
us
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Accès ouvert
2025
article
OpenAlex
Sofie Kessels, Chloë Trippaers, Melanie Mertens, Ibrahim Hamad et autres
Synaptic dysfunction is a hallmark of neurodevelopmental disorders (NDDs), often linked to genes involved in cytoskeletal regulation. While the role of these genes has been extensively studied in neurons, microglial functions such as phagocytosis are also dependent on cytoskeletal dynamics. We demonstrate …
be, us, nl, ca
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2025
preprint
OpenAlex
Rupali Srivastava, Nathaniel Genduso, Koko Ishizuka, Akira Sawa
ABSTRACT Bipolar disorder (BP) is a severe mental illness featured with potential cycling of depressive and manic episodes. The recurrent cycling is known to be associated with poor prognosis. Thus, it is important to decipher the pathophysiological mechanism that may possibly underlie …
us
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Accès ouvert
2025
article
OpenAlex
Kun Yang, Koko Ishizuka, Toshifumi Tomoda, Akira Sawa
Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic …
us, ca
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Accès ouvert
2025
article
OpenAlex
Leslie G. Nucifora, Koko Ishizuka, Nagat El Demerdash, Brian J. Lee et autres
Schizophrenia is a heterogeneous disorder, and likely results from multiple pathophysiological mechanisms. Protein aggregation, resulting from disruption of protein homeostasis (proteostasis), has been implicated in many diseases, including cancer, cardiac and pulmonary diseases, muscle diseases, and neurodegenerative disorders, but is a relatively …
us, ve, co
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Accès ouvert
2025
article
OpenAlex
Atsushi Saito, S Ishikawa, Kun Yang, Akira Sawa et autres
Sulforaphane (SFN), a bioactive compound derived from glucoraphanin in cruciferous vegetables such as broccoli, has been extensively studied for its therapeutic potential across diverse disease categories. SFN exerts its effects through well-characterised pathways, including the Keap1/Nrf2 axis, which regulates phase II detoxification …
us
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Accès ouvert
2024
erratum
OpenAlex
Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung et autres
The article Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility, written by Akira Sawa was originally published online on the publisher’s internet portal on 14.04.2024 with Open Access under a Creative Commons Attribution (CC BY) license 4.0.
us, jp
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Accès ouvert
2024
article
OpenAlex
Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung et autres
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress in which deficits in rule shifting tasks were elicited, the nuclear glyceraldehyde dehydrogenase (N-GAPDH) cascade was activated specifically in microglia in …
us, jp
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