Toshifumi Tomoda

Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume

Emily JY Kuik, Catalina Baena-Tan, Sho Moriguchi, Joeffre Braga et autres

Abstract Monoamine oxidase B (MAO-B) is a high-density protein located mainly in astrocytes that influences mitochondrial function and transition to astrogliosis. MAO-B produces hydrogen peroxide while metabolizing non-serotonergic monoamines. Elevated MAO-B level is implicated in the pathophysiology of several common neuropsychiatric diseases. …

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Molecular Characterization of the Progressive Landscape of Depression

Vandana Sharma, Elena Payna, Sébastien Garcia, Lauren Fang et autres

Major Depressive Disorder (MDD) frequently follows a recurrent trajectory of episodes and remissions, often culminating in treatment-resistance. Molecular differences defining state-specific changes during episode and remission have been explored. However, progressive differences-defined here as cross-sectional linear trends across clinical stages from first …

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Autophagy in Stress-Induced Neuropsychiatric Disorders and Depression

Akira Sawa, Kun Yang, Nicola G. Cascella, Toshifumi Tomoda

This article discusses how autophagic mechanisms mediate neurobiological and behavioral changes in stress-induced neuropsychiatric disorders and depression.

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Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis

Kun Yang, Koko Ishizuka, Toshifumi Tomoda, Akira Sawa

Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic …

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Impact of feeding age on cognitive impairment in mice with Disrupted-In-Schizophrenia 1 (Disc1) mutation under a high sucrose diet

Jong-Hyuk Park, Hiroko Shimbo, Shoko Tamura, Toshifumi Tomoda et autres

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Behavioral and Neurochemical Effects of Increased MAOA Activity in the Prefrontal Cortex in Mice

Rodolphe Lebeau, Runhao Zhou, Jeffrey H. Meyer, Toshifumi Tomoda et autres

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Modeling elevated MAO-A activity in mice: role in emotionality and antidepressant treatment response

R Lebeau, Rong Zhou, Etienne Sibille, Jeffrey H. Meyer et autres

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Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress

Xiaolu Zhang, Mahmoud Ali Eladawi, William G. Ryan, Xiaoming Fan et autres

The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting the need for a conceptual framework that can explain this variability and bridge the gap between animal models and clinical endpoints. Here, we …

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BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain

Akiko Sumitomo, Runhao Zhou, Thomas D. Prévot, Etienne Sibille et autres

Anxiety is a state of emotion that variably affects animal behaviors, including cognitive functions. Behavioral signs of anxiety are observed across the animal kingdom and can be recognized as either adaptive or maladaptive responses to a wide range of stress modalities. Rodents …

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Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress

Xiaolu Zhang, Mahmoud Ali Eladawi, William G. Ryan, Xiaoming Fan et autres

Abstract The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting the need for a conceptual framework that can explain this variability and bridge the gap between animal models and clinical endpoints. Here, …

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Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science

Kun Yang, Koko Ishizuka, Andrew P. Lane, Zui Narita et autres

ABSTRACT Biopsy is crucial in clinical medicine to obtain tissues and cells that directly reflect the pathological changes of each disease. However, the brain is an exception due to ethical and practical challenges. Nasal biopsy, which captures the olfactory neuronal epithelium, has …

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Synthesis and biological activity of a novel compound to treat psychological disorders and memory reduction

Prithu Mondal, Yeunus Mian, Kamal Prasad Pandey, Dishary Sharmin et autres