Huilai Miao

Dynamic graph representation learning based on multi-scale attention

Pingtao Duan, Yanqun Wu, Jiayi Wei, Jing Tian et autres

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Metabolic dysfunction-associated steatotic liver disease and risk of gallstone disease: A systematic review and meta-analysis

杨谢超, Qunyu Huang, Yan Wang, Huilai Miao

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease, NAFLD) and gallstone disease (GD) share common pathophysiological underpinnings of metabolic dysregulation. However, the epidemiological strength of their association, dose-response relationship, and subgroup differences remain incompletely assessed. This study …

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Risk Factor Analysis and Nomogram for Predicting 28-day in-hospital Mortality in ICU Patients with Liver Necrosis

Fanbing Wang, Haohong Huang, N Liu, Huilai Miao

INTRODUCTION: The mortality risk factors in intensive care unit (ICU) patients with liver necrosis (LN) remain unclear. This study aimed to develop a prediction model for mortality risk in LN patients to assist clinical practice. METHODS: We enrolled 1153 acute and subacute …

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The impact of serum interleukin-17a as a predictive biomarker for neoadjuvant therapy response in breast cancer: a retrospective study

Liyan Yu, Zhongzeng Liang, Xiangning Zeng, Guoqing Liu et autres

Background: Breast cancer (BC) is a common and highly malignant disease. Recently, interlukin-17a (IL-17a) was found to be associated with several human malignancies. However, the role of IL-17a in predicting treatment response in BC patients undergoing neoadjuvant therapy (NAT) remains unclear, with …

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Recent Advances in Fluorescence Resonance Energy Transfer (FRET) Biosensors for Exosomes

Feng Huang, Zhenyu Xie, Shah Zada, Rujian Lin et autres

Cancer is a significant global health challenge, where early diagnosis is crucial for enhancing patient survival and mitigating the treatment burden on patients. Exosomes are extracellular vesicles released through the fusion of multivesicular bodies with cell membranes, carrying disease-associated information from donor …

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MEF2C is a Potential Prognostic Biomarker and is Correlated with Immune Infiltrates in Lung Adenocarcinoma

Ke Liang, Rui Xie, Zhanqiang Xie, Wang Wan et autres

BACKGROUND: The role of Myocyte Enhancer Factor 2 C (MEF2C) in lung adenocarcinoma (LUAD) is unclear. OBJECTIVE: To address this gap in knowledge, we employed bioinformatics analysis and experimental validation in this study. METHODS: This study investigated MEF2C expression across a spectrum …

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Hydrogel Loaded with Extracellular Vesicles: An Emerging Strategy for Wound Healing

Yucan Yang, Huizhi Chen, Yunjie Li, Junting Liang et autres

An increasing number of novel biomaterials have been applied in wound healing therapy. Creating beneficial environments and containing various bioactive molecules, hydrogel- and extracellular vesicle (EV)-based therapies have respectively emerged as effective approaches for wound healing. Moreover, the synergistic combination of these …

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The roles and mechanisms of APOL1 in the development of colorectal cancer

Feipeng Xu, Weiwei Wang, Qidong Li, Lirui Zou et autres

Background: Research has demonstrated that apolipoprotein L1 (APOL1) has a role in the emergence and progression of a number of malignant cancers. It is unclear, however, how APOL1 functions in colorectal cancer (CRC). In this study, we examined the possible molecular processes …

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Prognostic role of plasma IL-17a expression and neoadjuvant therapy efficacy in breast cancer

Liyan Yu, Huilai Miao, Xiangning Zeng, Guoqing Liu et autres

MiR-34a ameliorates arterial blood flow in rats with lower limb arteriosclerosis obliterans via Sirt1 signaling pathway

Tuo Xu, Changwei Zheng, Yongkang Wu, Zhengde Chen et autres

In this study, we investigated the impact of microRNA-34a (miR-34a) on lower limb arteriosclerosis obliterans in rats through the Sirtuin 1 (Sirt1) signaling pathway. Thirty-six Sprague-Dawley rats were divided into normal, model, and miR-34a mimics groups. Rats in the normal group were …

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SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23

Yongkang Wu, Weijie Chen, Huilai Miao, Tuo Xu

OBJECTIVE: This study was designed to investigate the regulatory effects of kinesin family member (KIF) 23 on anaplastic thyroid cancer (ATC) cell viability and migration and the underlying mechanism. METHODS: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to analyze the levels …

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Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

Shengwen Shao, Huilai Miao, Wenxue Ma

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While …

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