Sachiko Suzuki

Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model

Nobuaki Suzuki, Atsuo Suzuki, Shogo Tamura, Sena Tokumaru et autres

BACKGROUND: Antithrombin resistance (ATR) is a congenital thrombotic predisposition caused by abnormal prothrombin, FII (Factor II). Abnormal FII with ATR characteristics, when converted to thrombin, FIIa (Factor IIa), shows a reduced affinity of binding to AT (antithrombin), resulting in reduced anti-FIIa and …

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EP.14.09 Comparison Between Epithelioid Type and Biphasic Type in Pleurectomy/Decortication for Pleural Mesothelioma

Kazunori Okabe, Sachiko Suzuki, Hiroaki Komatsu

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Aberrant X chromosomal rearrangement through multi‐step template switching during sister chromatid formation in a patient with severe hemophilia A

Mahiru Tokoro, Shogo Tamura, Nobuaki Suzuki, Misaki Kakihara et autres

BACKGROUND: Hemophilia A (HA) is an X-linked recessive bleeding disorder caused by pathogenic variants of the coagulation factor VIII gene (F8). Half of the patients with severe HA have a recurrent inversion in the X chromosome, that is, F8 intron 22 or …

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Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy

Mika Ogawa, Nobuaki Suzuki, Nobunori Takahashi, Shogo Tamura et autres

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Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors

Shuichi Okamoto, Nobuaki Suzuki, Atsuo Suzuki, Sachiko Suzuki et autres

We managed perioperative hemostasis for a 72-year-old man with hemophilia A and low inhibitor titers (3 BU/mL), who underwent osteosynthesis for supracondylar fracture of the left humerus. He was treated perioperatively using the combination of high doses of factor VIII (FVIII) with …

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Apparent synonymous mutation F9 c.87A>G causes secretion failure by in-frame mutation with aberrant splicing

Koya Odaira, Shogo Tamura, Nobuaki Suzuki, Misaki Kakihara et autres

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Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency

Shogo Tamura, Erika Hashimoto, Nobuaki Suzuki, Misaki Kakihara et autres

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Neutron Reflectometry Study of Penetration of Protective Coating Material by Deuterated Sodium Pyruvate

Kazuhiro Akutsu-Suyama, Yoshio Hasegawa, Tomotake Niizeki, Sachiko Suzuki et autres

We studied the penetration of organic stains into a protective silica coating layer using a neutron reflectivity (NR) technique.First, we performed nuclear magnetic resonance, mass spectrometry, and elemental analysis of deuterated sodium pyruvate (NaPyr-d 3 ) to estimate its scattering length density …

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Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study

Dai Watanabe, Tomoko Uehira, Sachiko Suzuki, Erina Matsumoto et autres

Circulating interferon-γ (IFN-γ) concentration may be sustained at a high level regardless of the initiation of antiretroviral therapy (ART) in some patients with HIV-1 infection. In the present study, we examined the clinical characteristics of HIV-1-infected patients with high levels of plasma …

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Optimisation of antithrombin resistance assay as a practical clinical laboratory test: Development of prothrombin activator using factors Xa/Va and automation of assay

Shogo Tamura, Yanto Suga, M. Tanamura, Moe Murata-Kawakami et autres

Abstract Introduction Antithrombin resistance (ATR) is a novel thrombotic risk in abnormal prothrombins. A manual ATR assay using Oxyuranus scutellatus (Ox) venom as a prothrombin activator was established for detecting antithrombin‐resistant prothrombin. However, this assay was limited because of Ox snake venom …

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Corrosion behavior of arc welded joints of chassis parts and an approach to improve its corrosion resistance

Shunsuke Yamamoto, Sachiko Suzuki, Satoru Ando, Rinsei Ikeda et autres

Reducing auto body weight by use of high strength steel is an important issue. Although it is necessary to increase the strength of steel sheets for underbody parts, use of high strength steel sheets has not progressed sufficiently due to the problems …

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In vitro exploration of latent prothrombin mutants conveying antithrombin resistance

Shogo Tamura, Moe Murata-Kawakami, Yuki Takagi, Sachiko Suzuki et autres

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