Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Circulating interferon-γ (IFN-γ) concentration may be sustained at a high level regardless of the initiation of antiretroviral therapy (ART) in some patients with HIV-1 infection. In the present study, we examined the clinical characteristics of HIV-1-infected patients with high levels of plasma IFN-γ. The study subjects were patients infected with HIV-1 who were either naïve to ART with CD4 + cell count > 200 cells/μL ( n = 12), or had achieved viral suppression after ART for over a year ( n = 188). The levels of plasma IFN-γ and interleukin-6 (IL-6) were measured by the enzyme-linked immunosorbent assay. Patients were divided into high IFN-γ and low IFN-γ groups based on a cutoff level of 5 pg/mL. The high IFN-γ group included 41 patients (21%). Compared to the patients on ART with low IFN-γ levels, those on ART in the high IFN-γ group were more likely to be younger than 50 years of age ( P = 0.0051) and less likely to have dyslipidemia ( P = 0.0476) or to be on a protease inhibitor ( P = 0.0449). There was no significant difference between groups in the median increase of CD4 + cell counts from the initiation of ART for up to 3 years. However, after 4 years, the increase in CD4 + cell counts was significantly lower in the high IFN-γ group compared with that in the low IFN-γ group. There were no such significant differences between patients with low and high (> 2 pg/mL) levels of plasma IL-6. We concluded that HIV-1-infected patients with high levels of circulating IFN-γ did not have a higher rate of comorbidities related to immune activation. However, they exhibited lower CD4 + cell count recovery after 4 years of being on ART. This deficit could be a consequence of persistent immune activation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study
- Date Crossref
- 05/01/2019
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osaka National Hospital pays non établi dans la noticeÉtablissement de santé
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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National Kyushu Medical Center pays non établi dans la noticeÉtablissement de santé
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National Hospital Organization pays non établi dans la noticeOrganisme public
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AIDS Medical Center pays non établi dans la noticeÉtablissement de santé
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Osaka University Graduate School of Medicine Department of Advanced Medicine for HIV Infection pays non établi dans la noticeUniversité ou école supérieure
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Clinical Research Institute Internal Medicine pays non établi dans la noticeStructure de recherche
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National Organization Kanmon Medical Center Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
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Department of Clinical Research pays non établi dans la noticeÉtablissement de santé
Osaka National Hospital, The University of Osaka et National Kyushu Medical Center, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.