Rui Shi

A novel approach for benign parotid tumors: a dual-focused strategy on functional preservation and aesthetics

Rui Shi, Wenhao Ren, Shaoming Li, Ling Gao

OBJECTIVE: Benign tumors of the parotid gland are the most common salivary gland diseases, Conventional parotid surgery often leads to various complications that severely affect the postoperative quality of life of patients. METHODS: This study included 400 patients with clinically benign tumors …

cn (code pays fourni par la source)

Construction of Molecular Pathway Network for Cerebral Ischemia and Reperfusion and Screening of Potential Targeted Drugs.

Qiming Liu, Ye Tian, Rui Shi, Yiting Gu et autres

OBJECTIVE: To elucidate the molecular mechanisms underlying ischemia-reperfusion (I/R) injury and explore novel therapeutic targets. METHODS: Raw counts from control, middle cerebral artery occlusion (MCAO), and MCAO+drug groups were processed via the Differential Expression analysis for Sequence data, version 2 (DESeq2) pipeline. …

cn (code pays fourni par la source)

NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage

Jin Cong, Lihui Liu, Rui Shi, Mengting He et autres

Excessive stress disrupts cardiac homeostasis via complex and multifactorial mechanisms, resulting in cardiac dysfunction, cardiovascular disease, or even sudden cardiac death, yet the underlying molecular mechanisms remain poorly understood. Accordingly, we aimed to elucidate how stress induces calcium dysregulation and contributes to …

cn (code pays fourni par la source)

Organic cocrystals in the NIR window: functional design, controlled synthesis and frontier applications

Rui Shi, Wanglong Hong, Shengli Zhu, Zhenduo Cui et autres

cn (code pays fourni par la source)

NR3C1/PRKACG-mediated impairment of mitochondrial quality control underlies stress-induced hypothalamic neuronal injury

Guowei Zhang, Jin Cong, Xiaowei Feng, Hongjian Xin et autres

cn (code pays fourni par la source)

Ultrasound indicates imbalance of superficial posterior cervical muscles: a sign of cervical degenerative instability

Guodong Chen, Yaolong Chen, Xin Wang, Rui Shi

OBJECTIVE: This study aimed to explore the association between changes in elasticity and thickness of the superficial posterior cervical muscles and cervical degenerative instability (CDS). CDS is primarily managed non-surgically, including manual and traction therapies. Thus, a diagnostic method to guide targeted …

cn (code pays fourni par la source)

Key strategies for determining surgical resection margins in OSCC

Rui Shi, Wenhao Ren, Keqian Zhi

cn (code pays fourni par la source)

Stress-Induced Cholesterol Metabolic Dysregulation and Differentiation Trajectory Shift in Oligodendrocytes Synergistically Drive Demyelination

Weihao Zhu, Rui Shi, Yingmin Li, Guowei Zhang et autres

Stress-induced demyelination resulting from oligodendrocyte (OLG) dysfunction is one of the key pathological mechanisms of depression, yet its dynamic regulatory network remains unclear. This study integrates single-cell transcriptomics, lineage tracing, and functional interventions to uncover a temporally disordered OLG cholesterol metabolism in …

cn (code pays fourni par la source)

Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020)

Rui Shi, Ye Tian, Qiming Liu, Jiayun Zhang et autres

Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response is an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and stroke. Methods We collected data on participants with SII …

cn (code pays fourni par la source)

Analysis of anterior segment in primary angle closure suspect with deep learning models

Ziwei Fu, Jinwei Xi, Zhi Ji, Ruxue Zhang et autres

OBJECTIVE: To analyze primary angle closure suspect (PACS) patients' anatomical characteristics of anterior chamber configuration, and to establish artificial intelligence (AI)-aided diagnostic system for PACS screening. METHODS: A total of 1668 scans of 839 patients were included in this cross-sectional study. The …

cn, us (code pays fourni par la source)

Identification and Verification of the Oxidative Stress-Related Signature Markers for Intracranial Aneurysm-Applied Bioinformatics

Pengxin Duan, Bo Nie, Zhe Zhang, Rui Shi et autres

BACKGROUND: Intracranial aneurysm (IA) is a localized abnormal dilation of the cerebral vascular wall, the degeneration of which is closely related to high oxidative stress. METHODS: Clinical information and RNA-seq data from five public datasets were downloaded from the Gene Expression Omnibus …

cn (code pays fourni par la source)

Studies related to the enhanced the effect of 5-aminolevulinic acid-based photodynamic therapy combined with tirapazamine

Qian Wang, Yuping Suo, Rui Shi, Yulan Wang

OBJECTIVE: 5-aminolevulinic acid (5-ALA) is a precursor of the photosensitizer Protoporphyrin IX (PpIX) and photodynamic therapy (PDT) with 5-ALA has been used in clinical practice. However, tumor cellular hypoxia severely affects the efficiency of photodynamic therapy. In this study, photodynamic therapy was …

cn (code pays fourni par la source)