Lihui Liu

Awakening antitumour immunity in the multimorbid host: a hypothesis coupling cryoablation-induced immunogenic cell death with multi-target Traditional Chinese Medicine

Lihui Liu, Honglin Chen, Jingxiao Wang, Jingjing Yang et autres

Most patients with cancer are older adults living with several other chronic illnesses, and both the tumour and its commonest companions—cardiometabolic disease, type 2 diabetes and depression—are sustained by a shared, immunosuppressive inflammatory milieu. In this setting many tumours are immunologically “cold”: …

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The efficacy and safety of sosimerasib monotherapy in pretreated colorectal cancer with KRAS G12C mutation: Results from a phase 1b study.

Lihui Liu, Shanxian Guo, Conghua Xie, Pingli Wang et autres

3596 Background: KRAS G12C mutation is a key driver in approximately 3-4% of colorectal cancer (CRC) cases with poor prognosis. Sosimerasib is a novel, potent, and highly selective KRAS G12C inhibitor. This Phase 1b study evaluates the efficacy and safety of sosimerasib …

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Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research

Zhiyan Liang, Jing Yang, Ye Zhou, Zhiwei Zhou et autres

Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) are generally resistant to targeted therapy with tyrosine kinase inhibitors (TKIs), such as imatinib, and there are no standard therapeutic options for advanced SDH-deficient GISTs. The precise oncogenic mechanisms of SDH mutations in GIST have …

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Bidens pilosa Is a New Natural Host of Telosma Mosaic Virus in China

H. Xie, Youcong Li, Cuiping Mo, Jinqing Chen et autres

Telosma mosaic virus (TelMV), a member of the genus Potyvirus (family Potyviridae), is an emerging virus infecting a variety of natural hosts. This virus has been reported to infect Passiflora edulis (Chiemsombat et al. 2014), Pogostemon cablin (Noveriza et al. 2016), Senna …

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60P Longitudinal dynamics of the gut microbiome and dietary associations in immunotherapy-treated hepatobiliary cancer patients

Joycelyn Jie Xin Lee, Lihui Liu, Sue Fen Kwa, Sang Yeoup Lee et autres

The gut microbiome influences host immunity and response to immune checkpoint inhibitors (ICI). Previously we described baseline microbial and dietary predictors of ICI treatment response in patients with hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Here, we describe the longitudinal changes in key …

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1423P Real-world evidence of neoadjuvant immunotherapy in high-risk locoregionally advanced nasopharyngeal carcinoma: A propensity score-matched analysis

Zhichao Wu, Lai Wang, Qianyu He, Leo Y. Luo et autres

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CN33 Enhancing patient outcomes through preoperative nursing education

Lihui Liu

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NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage

Jin Cong, Lihui Liu, Rui Hua Shi, Mengting He et autres

Excessive stress disrupts cardiac homeostasis via complex and multifactorial mechanisms, resulting in cardiac dysfunction, cardiovascular disease, or even sudden cardiac death, yet the underlying molecular mechanisms remain poorly understood. Accordingly, we aimed to elucidate how stress induces calcium dysregulation and contributes to …

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Otherness and Gender Subjugation in Antony and Cleopatra

Lihui Liu, Hafiz Muhammad Sikandar

Indeed, a significant disjunction is present between the Orient and the Occident; Orientalism by Said is a thorough example of this strong argument. Ethnic and gender hierarchies entangle the two great noble persons from East and West, turning into a fire that …

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Aripiprazole-Associated Rhabdomyolysis

Jieru Ren, Jing Nie, Lihui Liu, Lei Sun et autres

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The complete chloroplast genomes of Petrocodon mirus and Petrocodon hancei (Gesneriaceae)

Y. Qi, Ying Wei, Lihui Liu

The genus Petrocodon is uniquely distributed in karst areas and exhibits high floral morphological diversity. We assembled and characterized the complete chloroplast genomes of Petrocodon mirus X.Z.Shi, J.X.Fu & L.H.Yang 2024 and Petrocodon hancei (Hemsl. 1890) A.Weber & Mich.Möller 2011. The genome …

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Development, validation, and clinical utility of risk prediction models for cancer-associated venous thromboembolism: A retrospective and prospective cohort study

Shuai Jin, Dan Qin, Chong Wang, Baosheng Liang et autres

Objectives This study aims to develop cancer-associated venous thromboembolism (CA-VTE) risk prediction models using survival machine learning (ML) algorithms. Methods This study employed a double-cohort study design (retrospective and prospective). The retrospective cohort ( n ​= ​1036) was used as training set …

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