Yuping Suo

INHBA secreted by cancer-associated fibroblasts promotes cisplatin resistance and malignant progression of ovarian cancer via ENG-mediated suppression of apoptosis and induction of EMT

Xinyue Liu, Han Yan, Zhichao Qin, Xinghua Li et autres

BACKGROUND: Platinum resistance remains a major cause of treatment failure in ovarian cancer (OC). Cancer-associated fibroblasts (CAFs), key components of the tumor microenvironment, play critical roles in OC progression. Inhibin subunit beta A (INHBA) and its putative receptor endoglin (ENG) have been …

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Suppressor of cytokine signaling 6 (SOCS6) mediates ubiquitination degradation of SLC7A11 to drive ferroptosis and block lipid metabolism in ovarian cancer cells

Yuping Suo

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DDIAS promotes endometrial cancer progression via β-catenin signaling

Xiaojuan Tian, Menglu Liu, Jiangbo Zhao, Boya Liu et autres

BACKGROUND: DDIAS has been recognized as an oncogene in various cancers, but its role in endometrial cancer remains unexplored. METHODS: The expression of DDIAS in normal endometrium and endometrial cancer samples was analysed via the The Cancer Genome Atlas (TCGA) database, and …

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Paeonol protects against cisplatin-induced premature ovarian failure via anti-inflammatory and antioxidant activities: an integrated approach of network pharmacology, molecular dynamics simulation, and experimental validation

Xinyue Liu, Yan Han, Xinhui Tang, Yun Ren et autres

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5-Aminolaevulinic Acid-Mediated Photodynamic Therapy Combined with Tirapazamine Enhances Efficacy in Ovarian Cancer

Qian Wang, Yuping Suo, Xiaojuan Tian

Objectives: Ovarian cancer is a common gynaecological malignancy. Photodynamic therapy (PDT) mediated by 5-aminolaevulinic acid (5-ALA-PDT) is widely used in clinical practice. However, hypoxia may impact the efficacy of this treatment. In the present study, we combined the bioreductively active drug tirapazamine …

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Studies related to the enhanced the effect of 5-aminolevulinic acid-based photodynamic therapy combined with tirapazamine

Qian Wang, Yuping Suo, Rui Hua Shi, Yulan L. Wang

OBJECTIVE: 5-aminolevulinic acid (5-ALA) is a precursor of the photosensitizer Protoporphyrin IX (PpIX) and photodynamic therapy (PDT) with 5-ALA has been used in clinical practice. However, tumor cellular hypoxia severely affects the efficiency of photodynamic therapy. In this study, photodynamic therapy was …

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Cell Cycle-Related Centromere Protein F Deficiency Suppresses Ovarian Cancer Cell Growth by Inducing Ferroptosis

Xinyue Liu, Li Guo, Yuping Suo, Xinhui Tang et autres

OBJECTIVES: This study aimed to investigate the involvement of the cell cycle-related protein centromere protein F (CENPF) in the development of ovarian cancer (OC) and explored its relationship with ferroptosis. DESIGN: The databases were analysed to identify differential expression of cell cycle-related …

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Porphin e6 complex loaded with gold nanorod mesoporous silica enhances photodynamic therapy in ovarian cancer cells in vitro

Qian Sun, Yuping Suo, Haoxuan Lv, Qian Wang et autres

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Study on the effect of 5-aminolevulinic acid-mediated photodynamic therapy combined with cisplatin on human ovarian cancer OVCAR-3 cells

Haoxuan Lv, Yuping Suo, Qian Sun, Jingjing Fan et autres

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Study on the mechanism of photodynamic therapy mediated by 5-aminoketovalerate in human ovarian cancer cell line

Qian Wang, Yuping Suo, Xiaoni Wang, Yulan L. Wang et autres

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Nanoparticles loading porphyrin sensitizers in improvement of photodynamic therapy for ovarian cancer

Rui Liu, Yanxia Gao, Nannan Liu, Yuping Suo

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Effects and diagnostic value of G protein-coupled receptor 4 on the establishment of neovascularization of human papillomavirus infection in cervical cancer tissues

Fulian Li, Yuping Suo, Mouxiang Wang, Yuxiu Wang et autres

Objective To explore the effect and diagnostic value of G protein coupled receptor 4 (LGR4) on the establishment of neovascularization of HPV infected cervical cancer tissue. Methods From March 2016 to December 2017, thirty cases of HPV infected cervical cancer, cervical precancerous …